Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.72 |
| ▸ | DRD3 | P35462 | 5/20 | 0.72 |
| ▸ | HTR1A | P08908 | 2/20 | 0.72 |
| ▸ | HTR2A | P28223 | 1/20 | 0.72 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.72 |
| ▸ | HTR7 | P34969 | 1/20 | 0.72 |
| ▸ | HRH1 | P35367 | 1/20 | 0.72 |
| ▸ | BCHE | P06276 | 1/20 | 0.68 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.68 |
| ▸ | DRD4 | P21917 | 4/20 | 0.67 |
| ▸ | HTR6 | P50406 | 1/20 | 0.63 |
| ▸ | HTT | P42858 | 4/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.62 |
| ▸ | LMNA | P02545 | 3/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | JAK2 | O60674 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 1/20 | 0.61 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8872774 | 0.90 | BCHE (0.73) | DRD2DRD3HTR1AHTR2ASLC6A4 | |
| SCHEMBL734941 | 0.86 | HTR2A (0.85) | DRD2DRD3HTR1AHTR2ASLC6A4 | |
| SCHEMBL6969248 | 0.86 | BCHE (0.57) | DRD2DRD3HTR1AHTR2ASLC6A4 | |
| SCHEMBL13302413 | 0.84 | DRD3 (0.56) | DRD2DRD3HTR1AHTR2ASLC6A4 | |
| SCHEMBL8872939 | 0.84 | ADRA1D (0.60) | DRD2DRD3HTR1AHTR2ASLC6A4 | |
| SCHEMBL20359039 | 0.84 | HTR1A (1.00) | DRD2DRD3HTR1AHTR2ASLC6A4 | |
| SCHEMBL1387913 | 0.80 | DRD4 (1.00) | DRD2DRD3HTR1AHTR2AHTR7 | |
| SCHEMBL8557392 | 0.79 | ALDH1A1 (0.66) | DRD2DRD3HTR1AHTR2ASLC6A4 | |
| SCHEMBL1849016 | 0.79 | LMNA (0.90) | DRD2DRD3HTR2ABCHECYP2D6 | |
| SCHEMBL10463380 | 0.79 | LMNA (0.97) | DRD2DRD3HTR2ABCHECYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5641787-A | Indole derivatives as dopamine D4 antagonists | MERCK, SHARP & DOHME LTD. (GB) | 1997-06-24 | — | — | US | claimed |
| WO-1994021628-A1 | INDOLE DERIVATIVES AS DOPAMINE D4 ANTAGONISTS | MERCK SHARP & DOHME LIMITED (GB) | 1994-09-29 | — | — | WO | claimed |
| US-5641787-A | Indole derivatives as dopamine D4 antagonists | MERCK, SHARP & DOHME LTD. (GB) | 1997-06-24 | — | — | US | disclosed |