Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.69 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | BACE1 | P56817 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13879639 | 0.80 | KDM4E (0.64) | CYP3A4CYP2C19ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL13879614 | 0.79 | CYP3A4 (0.64) | CYP3A4CYP2C19ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL4276357 | 0.78 | RAB9A (0.55) | ALDH1A1KDM4ESMN1; SMN2HPGDBACE1 | |
| SCHEMBL4276363 | 0.78 | RAB9A (0.55) | ALDH1A1KDM4ESMN1; SMN2HPGDBACE1 | |
| SCHEMBL13879633 | 0.77 | ITGB2 (0.59) | CYP3A4CYP2C19SMN1; SMN2LMNAKMT2A | |
| SCHEMBL13879650 | 0.76 | CYP3A4 (0.62) | CYP3A4CYP2C19ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL4280119 | 0.73 | ALDH1A1 (0.58) | CYP3A4CYP2C19ALDH1A1KDM4ELMNA | |
| SCHEMBL4280125 | 0.73 | ALDH1A1 (0.58) | CYP3A4CYP2C19ALDH1A1KDM4ELMNA | |
| SCHEMBL1647252 | 0.73 | BACE1 (0.80) | ALDH1A1SMN1; SMN2KMT2AMAPTMEN1 | |
| SCHEMBL1647249 | 0.73 | BACE1 (0.80) | ALDH1A1SMN1; SMN2KMT2AMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102304075-A | Inhibitors of viral replication | INTERMUNE INC | 2012-01-04 | — | — | CN | disclosed |
| US-20090099186-A1 | INHIBITORS OF VIRAL REPLICATION | INTERMUNE, INC. | 2009-04-16 | — | — | US | disclosed |
| US-20090099186-A1 | INHIBITORS OF VIRAL REPLICATION | INTERMUNE, INC. | 2009-04-16 | — | — | US | disclosed |
| CN-101304976-A | Inhibitors of viral replication | INTERMUNE INC (US) | 2008-11-12 | — | — | CN | disclosed |
| WO-2007047146-A2 | INHIBITORS OF VIRAL REPLICATION | INTERMUNE, INC. (US) | 2007-04-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090099186-A1 | INHIBITORS OF VIRAL REPLICATION | EIF2AK2, HAVCR2, RTF2 | CYP3A4 1385/4885CYP2C19 2487/4885ALDH1A1 1500/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.