Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 4/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.39 |
| ▸ | SLC6A1 | P30531 | 1/20 | 0.39 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.39 |
| ▸ | SLC6A11 | P48066 | 1/20 | 0.39 |
| ▸ | SLC6A13 | Q9NSD5 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19993072 | 0.74 | DRD2 (0.49) | DRD2DRD3CHRM5CHRM1CHRM3 | |
| SCHEMBL6816695 | 0.70 | KMT2A (0.55) | DRD2DRD3OPRM1 | |
| SCHEMBL10638230 | 0.69 | SIGMAR1 (0.43) | DRD2DRD3CHRM5CHRM1CHRM3 | |
| SCHEMBL2339483 | 0.67 | SLC6A4 (0.47) | HTTCHRM5CHRM1CHRM3SIGMAR1 | |
| SCHEMBL34463017 | 0.67 | SLC6A4 (0.47) | HTTCHRM5CHRM1CHRM3SIGMAR1 | |
| SCHEMBL9862636 | 0.67 | MEN1 (0.44) | SIGMAR1TP53 | |
| SCHEMBL6185984 | 0.67 | SLC6A4 (0.45) | OPRD1 | |
| SCHEMBL8747300 | 0.66 | SIGMAR1 (0.46) | HTTCHRM5CHRM1CHRM3SIGMAR1 | |
| SCHEMBL1245458 | 0.66 | APP (0.47) | HTTSIGMAR1OPRM1OPRD1OPRK1 | |
| SCHEMBL30040332 | 0.66 | HTT (0.67) | HTTSIGMAR1OPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1795527-B1 | CARBAMOYL-SUBSTITUTED SPIRO DERIVATIVE | BANYU PHARMA CO LTD (JP) | 2009-04-22 | — | — | EP | disclosed |