Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.49 |
| ▸ | DRD3 | P35462 | 2/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.45 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.44 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.43 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
| ▸ | DRD1 | P21728 | 2/20 | 0.43 |
| ▸ | DRD5 | P21918 | 2/20 | 0.43 |
| ▸ | SLC6A1 | P30531 | 1/20 | 0.41 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.41 |
| ▸ | SLC6A11 | P48066 | 1/20 | 0.41 |
| ▸ | SLC6A13 | Q9NSD5 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19291033 | 0.85 | SIGMAR1 (0.53) | SIGMAR1OPRD1OPRM1OPRK1OPRL1 | |
| SCHEMBL11919524 | 0.80 | SIGMAR1 (0.49) | SIGMAR1OPRD1OPRM1OPRK1OPRL1 | |
| SCHEMBL6816695 | 0.78 | KMT2A (0.55) | DRD2DRD3OPRM1 | |
| SCHEMBL1659035 | 0.77 | SIGMAR1 (0.68) | DRD2DRD3SIGMAR1OPRD1OPRM1 | |
| SCHEMBL30976388 | 0.77 | SIGMAR1 (0.68) | DRD2DRD3SIGMAR1OPRD1OPRM1 | |
| SCHEMBL10638230 | 0.76 | SIGMAR1 (0.43) | DRD2DRD3SIGMAR1OPRD1OPRM1 | |
| SCHEMBL11398635 | 0.75 | OPRM1 (0.49) | DRD2DRD3SIGMAR1OPRD1OPRM1 | |
| SCHEMBL6926820 | 0.75 | OPRD1 (0.44) | SIGMAR1OPRD1OPRM1OPRK1OPRL1 | |
| SCHEMBL6913497 | 0.74 | APP (0.47) | — | |
| SCHEMBL13880280 | 0.74 | DRD2 (0.41) | DRD2DRD3SIGMAR1OPRD1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2927214-B1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUND | KYOWA HAKKO KIRIN CO LTD (JP) | 2018-03-21 | — | — | EP | disclosed |