Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.44 |
| ▸ | HRH1 | P35367 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1388134 | 0.80 | KDM4E (0.43) | HTR2AHRH1KDM4EMEN1KMT2A | |
| SCHEMBL8798458 | 0.80 | TSHR (0.40) | HTR2AHRH1MEN1KMT2AMAPT | |
| SCHEMBL16207990 | 0.78 | TSHR (0.38) | KDM4ETSHRNOTUMALDH1A1RIPK1 | |
| Hydrochloric Acid SCHEMBL6986394 | 0.74 | KDM4E (0.54) | HTR2AHRH1KDM4EMEN1KMT2A | |
| SCHEMBL1387873 | 0.73 | RIPK1 (0.37) | HTR2AHRH1MEN1KMT2AMAPT | |
| SCHEMBL1387868 | 0.72 | TSHR (0.35) | KDM4EMEN1KMT2AMAPTL3MBTL1 | |
| SCHEMBL4019735 | 0.71 | HPGD (0.34) | TSHRSMN1; SMN2NOTUMRIPK1 | |
| SCHEMBL3762487 | 0.68 | MAPK1 (0.49) | MAPTPOLBHDAC1 | |
| SCHEMBL10780626 | 0.67 | SRD5A1 (0.41) | HTR2AHRH1KDM4EMEN1KMT2A | |
| SCHEMBL18350824 | 0.67 | MEN1 (0.62) | HTR2AKDM4EMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-H09501158-A | — | — | 1997-02-04 | — | — | JP | claimed |
| WO-1995004057-A1 | TRICYCLIC INHIBITORS OF THE GPIIbIIIa RECEPTOR | GENENTECH, INC. (US) | 1995-02-09 | — | — | WO | claimed |
| EP-0708775-B1 | TRICYCLIC INHIBITORS OF THE GPII b III a RECEPTOR | GENENTECH INC (US) | 1997-05-28 | — | — | EP | disclosed |
| EP-0708775-A1 | TRICYCLIC INHIBITORS OF THE GPII b III a RECEPTOR | GENENTECH INC (US) | 1996-05-01 | — | — | EP | disclosed |
| US-5493020-A | ANTICOAGULANTS | GENENTECH, INC. (US) | 1996-02-20 | — | — | US | disclosed |
| WO-1995004057-A1 | TRICYCLIC INHIBITORS OF THE GPIIbIIIa RECEPTOR | GENENTECH, INC. (US) | 1995-02-09 | — | — | WO | disclosed |