Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 8/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8798458 | 0.77 | TSHR (0.40) | TSHRTP53GAAMEN1KMT2A | |
| SCHEMBL16207990 | 0.75 | TSHR (0.38) | TSHRRIPK1GAAKDM4E | |
| SCHEMBL1387873 | 0.73 | RIPK1 (0.37) | TSHRRIPK1MEN1KMT2AMAPT | |
| SCHEMBL1388083 | 0.72 | HTR2A (0.44) | TSHRRIPK1MEN1KMT2AMAPT | |
| SCHEMBL4828036 | 0.69 | KDM4E (0.50) | TSHRMEN1KMT2AMAPTL3MBTL1 | |
| SCHEMBL3762487 | 0.68 | MAPK1 (0.49) | MAPT | |
| SCHEMBL3721702 | 0.67 | LMNA (0.45) | TSHRMAPTL3MBTL1KDM4E | |
| SCHEMBL16993485 | 0.67 | SLC6A3 (0.51) | MEN1KMT2AMAPTALOX15KDM4E | |
| SCHEMBL4019735 | 0.66 | HPGD (0.34) | TSHRRIPK1 | |
| Hydrochloric Acid SCHEMBL3719659 | 0.66 | LMNA (0.44) | TSHRMAPTL3MBTL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0708775-B1 | TRICYCLIC INHIBITORS OF THE GPII b III a RECEPTOR | GENENTECH INC (US) | 1997-05-28 | — | — | EP | claimed |
| JP-H09501158-A | — | — | 1997-02-04 | — | — | JP | claimed |
| EP-0708775-A1 | TRICYCLIC INHIBITORS OF THE GPII b III a RECEPTOR | GENENTECH INC (US) | 1996-05-01 | — | — | EP | claimed |
| WO-1995004057-A1 | TRICYCLIC INHIBITORS OF THE GPIIbIIIa RECEPTOR | GENENTECH, INC. (US) | 1995-02-09 | — | — | WO | claimed |
| EP-0708775-B1 | TRICYCLIC INHIBITORS OF THE GPII b III a RECEPTOR | GENENTECH INC (US) | 1997-05-28 | — | — | EP | disclosed |
| EP-0708775-A1 | TRICYCLIC INHIBITORS OF THE GPII b III a RECEPTOR | GENENTECH INC (US) | 1996-05-01 | — | — | EP | disclosed |
| WO-1995004057-A1 | TRICYCLIC INHIBITORS OF THE GPIIbIIIa RECEPTOR | GENENTECH, INC. (US) | 1995-02-09 | — | — | WO | disclosed |