Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | APAF1 | O14727 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.34 |
| ▸ | NPY1R | P25929 | 1/20 | 0.34 |
| ▸ | NPY2R | P49146 | 1/20 | 0.34 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.33 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1388083 | 0.80 | HTR2A (0.44) | TSHRHTR2AHRH1POLBNPC1 | |
| SCHEMBL1387868 | 0.77 | TSHR (0.35) | TSHRTP53GAANPC1RAB9A | |
| SCHEMBL16207990 | 0.75 | TSHR (0.38) | TSHRGAAALDH1A1 | |
| SCHEMBL1387873 | 0.73 | RIPK1 (0.37) | TSHRHTR2AHRH1NPC1RAB9A | |
| SCHEMBL3762487 | 0.68 | MAPK1 (0.49) | POLBMAPT | |
| SCHEMBL4019735 | 0.66 | HPGD (0.34) | TSHR | |
| SCHEMBL10780626 | 0.65 | SRD5A1 (0.41) | TSHRHTR2AHRH1NPC1RAB9A | |
| SCHEMBL18205236 | 0.63 | CARM1 (0.50) | POLBMAPTMEN1KMT2AL3MBTL1 | |
| SCHEMBL22639898 | 0.63 | HTR1A (0.57) | TSHRPOLBMAPTALDH1A1MEN1 | |
| SCHEMBL22639728 | 0.63 | HTR1A (0.57) | TSHRPOLBMAPTALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0708775-B1 | TRICYCLIC INHIBITORS OF THE GPII b III a RECEPTOR | GENENTECH INC (US) | 1997-05-28 | — | — | EP | disclosed |