Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 2/20 | 0.40 |
| ▸ | PPARD | Q03181 | 2/20 | 0.40 |
| ▸ | PPARA | Q07869 | 2/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 12/20 | 0.39 |
| ▸ | PTGDR | Q13258 | 3/20 | 0.38 |
| ▸ | RAPGEF4 | Q8WZA2 | 2/20 | 0.36 |
| ▸ | HTR6 | P50406 | 2/20 | 0.35 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.34 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.34 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3967784 | 0.80 | RAPGEF4 (0.35) | PPARGPPARDPPARAPTGDR2RAPGEF4 | |
| SCHEMBL3966252 | 0.79 | PTGDR2 (0.55) | PTGDR2PTGDRRAPGEF4 | |
| SCHEMBL13881864 | 0.79 | PTGDR2 (0.41) | PTGDR2PTGDRRAPGEF4HTR6 | |
| SCHEMBL3969343 | 0.77 | PTGDR2 (0.39) | PTGDR2PTGDRRAPGEF4HTR6 | |
| SCHEMBL3968730 | 0.77 | PTGDR2 (0.42) | PTGDR2PTGDRRAPGEF4HTR6 | |
| SCHEMBL3974788 | 0.76 | PTGDR2 (0.46) | PTGDR2PTGDRRAPGEF4 | |
| SCHEMBL3971663 | 0.75 | PTGDR2 (0.45) | PTGDR2PTGDRRAPGEF4HTR6 | |
| SCHEMBL3966242 | 0.75 | PTGDR2 (0.38) | PTGDR2PTGDRRAPGEF4HTR6 | |
| SCHEMBL3970095 | 0.74 | RAPGEF4 (0.43) | PTGDR2PTGDRRAPGEF4HTR6 | |
| SCHEMBL3972665 | 0.73 | PTGDR2 (0.38) | PTGDR2PTGDRRAPGEF4HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009044147-A1 | INDOLIZINE DERIVATIVES WITH CRTH2 RECEPTOR AFFINITY FOR THE TREATMENT OF INFLAMMATORY DISEASES | ARGENTA DISCOVERY LIMITED (GB) | 2009-04-09 | — | — | WO | disclosed |