Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAPGEF4 | Q8WZA2 | 3/20 | 0.35 |
| ▸ | PPARG | P37231 | 2/20 | 0.34 |
| ▸ | PPARD | Q03181 | 2/20 | 0.34 |
| ▸ | PPARA | Q07869 | 2/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | HTR6 | P50406 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.31 |
| ▸ | PPME1 | Q9Y570 | 1/20 | 0.31 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.31 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.31 |
| ▸ | ACLY | P53396 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3968885 | 0.92 | PPME1 (0.37) | RAPGEF4PTGDR2POLBHTR6MAPT | |
| SCHEMBL3967117 | 0.91 | POLB (0.36) | RAPGEF4PTGDR2POLBHTR6PPME1 | |
| SCHEMBL3967733 | 0.90 | PTGDR2 (0.40) | RAPGEF4PTGDR2PPME1MEN1KMT2A | |
| SCHEMBL3973994 | 0.89 | PTGDR2 (0.40) | RAPGEF4PTGDR2POLBHTR6MAPT | |
| SCHEMBL3967149 | 0.89 | RAPGEF4 (0.42) | RAPGEF4PTGDR2POLBPPME1AKR1C3 | |
| SCHEMBL3967602 | 0.87 | RAPGEF4 (0.34) | RAPGEF4PTGDR2POLBHTR6PPME1 | |
| SCHEMBL3968063 | 0.84 | HTR6 (0.34) | RAPGEF4PTGDR2POLBHTR6MAPT | |
| SCHEMBL3964361 | 0.82 | CYP3A4 (0.36) | RAPGEF4PTGDR2MAPT | |
| SCHEMBL3968730 | 0.82 | PTGDR2 (0.42) | RAPGEF4PTGDR2HTR6PPME1 | |
| SCHEMBL3969343 | 0.82 | PTGDR2 (0.39) | RAPGEF4PTGDR2HTR6PPME1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009044147-A1 | INDOLIZINE DERIVATIVES WITH CRTH2 RECEPTOR AFFINITY FOR THE TREATMENT OF INFLAMMATORY DISEASES | ARGENTA DISCOVERY LIMITED (GB) | 2009-04-09 | — | — | WO | disclosed |