Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13882471 | 0.86 | NR1I2 (0.37) | NR1I2MAPK14 | |
| SCHEMBL4311016 | 0.84 | NR1I2 (0.46) | NR1I2 | |
| SCHEMBL4322018 | 0.81 | NR1I2 (0.42) | NR1I2MAPK14 | |
| SCHEMBL13882473 | 0.79 | NR1I2 (0.35) | NR1I2MAPK14 | |
| SCHEMBL13882470 | 0.79 | RET (0.38) | NR1I2 | |
| SCHEMBL4312155 | 0.76 | TRPA1 (0.37) | — | |
| SCHEMBL4321125 | 0.72 | NR1I2 (0.41) | NR1I2MAPK14 | |
| SCHEMBL4309339 | 0.71 | GPR6 (0.35) | — | |
| SCHEMBL4309027 | 0.71 | BRD4 (0.37) | — | |
| SCHEMBL4315889 | 0.70 | HSPB1 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090088436-A1 | P38 Kinase Inhibiting Agents | MERCK SHARP & DOHME CORP. | 2009-04-02 | — | — | US | disclosed |
| US-20090088436-A1 | P38 Kinase Inhibiting Agents | MERCK SHARP & DOHME CORP. | 2009-04-02 | — | — | US | disclosed |
| US-7482345-B2 | P38 kinase inhibiting agents | MERCK SHARP & DOHME CORP. | 2009-01-27 | — | — | US | disclosed |
| US-7482345-B2 | P38 kinase inhibiting agents | MERCK SHARP & DOHME CORP. | 2009-01-27 | — | — | US | disclosed |
| US-20070129372-A1 | P38 kinase inhibiting agents | MERCK SHARP & DOHME CORP. | 2007-06-07 | — | — | US | disclosed |
| US-20070129372-A1 | P38 kinase inhibiting agents | MERCK SHARP & DOHME CORP. | 2007-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090088436-A1 | P38 Kinase Inhibiting Agents | MAPK1, MAPK8, MAPK7 | NR1I2 589/4885MAPK14 7/4885TDP1 360/4885 |
| US-20070129372-A1 | P38 kinase inhibiting agents | MAPK1, MAPK8, MAPK7 | NR1I2 589/4885MAPK14 7/4885TDP1 360/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.