Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 1/20 | 0.42 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.36 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.36 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
| ▸ | YES1 | P07947 | 1/20 | 0.36 |
| ▸ | LYN | P07948 | 1/20 | 0.36 |
| ▸ | HCK | P08631 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ROS1 | P08922 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | FGR | P09769 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13882473 | 0.92 | NR1I2 (0.35) | NR1I2MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL13882471 | 0.90 | NR1I2 (0.37) | NR1I2MAPK14 | |
| SCHEMBL4311016 | 0.90 | NR1I2 (0.46) | NR1I2 | |
| SCHEMBL13882467 | 0.81 | NR1I2 (0.37) | NR1I2MAPK14 | |
| SCHEMBL4304254 | 0.80 | HSPB1 (0.39) | — | |
| SCHEMBL22060078 | 0.77 | MAPK14 (0.62) | MAPK13MAPK12MAPK11MAPK14ABL1 | |
| SCHEMBL4311535 | 0.77 | MAPK14 (0.62) | NR1I2MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL4312155 | 0.76 | TRPA1 (0.37) | — | |
| SCHEMBL4321055 | 0.75 | NR1I2 (0.41) | NR1I2MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL4308128 | 0.75 | HSPB1 (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090088436-A1 | P38 Kinase Inhibiting Agents | MERCK SHARP & DOHME CORP. | 2009-04-02 | — | — | US | disclosed |
| US-20090088436-A1 | P38 Kinase Inhibiting Agents | MERCK SHARP & DOHME CORP. | 2009-04-02 | — | — | US | disclosed |
| US-20090088436-A1 | P38 Kinase Inhibiting Agents | MERCK SHARP & DOHME CORP. | 2009-04-02 | — | — | US | disclosed |
| US-7482345-B2 | P38 kinase inhibiting agents | MERCK SHARP & DOHME CORP. | 2009-01-27 | — | — | US | disclosed |
| US-7482345-B2 | P38 kinase inhibiting agents | MERCK SHARP & DOHME CORP. | 2009-01-27 | — | — | US | disclosed |
| US-7482345-B2 | P38 kinase inhibiting agents | MERCK SHARP & DOHME CORP. | 2009-01-27 | — | — | US | disclosed |
| EP-1963314-A2 | P38 KINASE INHIBITING AGENTS | Merck & Co., Inc. (US) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007067478-A2 | P38 KINASE INHIBITING AGENTS | MERCK & CO., INC. (US) | 2007-06-14 | — | — | WO | disclosed |
| WO-2007067478-A2 | P38 KINASE INHIBITING AGENTS | MERCK & CO., INC. (US) | 2007-06-14 | — | — | WO | disclosed |
| US-20070129372-A1 | P38 kinase inhibiting agents | MERCK SHARP & DOHME CORP. | 2007-06-07 | — | — | US | disclosed |
| US-20070129372-A1 | P38 kinase inhibiting agents | MERCK SHARP & DOHME CORP. | 2007-06-07 | — | — | US | disclosed |
| US-20070129372-A1 | P38 kinase inhibiting agents | MERCK SHARP & DOHME CORP. | 2007-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090088436-A1 | P38 Kinase Inhibiting Agents | MAPK1, MAPK8, MAPK7 | NR1I2 589/4885MAPK13 6/4885MAPK12 13/4885 |
| US-20070129372-A1 | P38 kinase inhibiting agents | MAPK1, MAPK8, MAPK7 | NR1I2 589/4885MAPK13 6/4885MAPK12 13/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.