Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GHSR | Q92847 | 4/20 | 0.68 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.68 |
| ▸ | XIAP | P98170 | 9/20 | 0.46 |
| ▸ | NPY1R | P25929 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1388243 | 0.92 | GHSR (0.59) | GHSRAGTR1XIAPNPY1R | |
| L-158432 SCHEMBL9023762 | 0.91 | GHSR (0.76) | GHSRAGTR1XIAPNPY1R | |
| L-158432 SCHEMBL7417293 | 0.91 | GHSR (0.76) | GHSRAGTR1XIAPNPY1R | |
| SCHEMBL9038320 | 0.90 | GHSR (0.55) | GHSRAGTR1XIAPNPY1R | |
| L-158432 SCHEMBL9108116 | 0.89 | GHSR (0.74) | GHSRAGTR1XIAPNPY1R | |
| L-158432 SCHEMBL9023941 | 0.87 | GHSR (0.71) | GHSRAGTR1XIAPNPY1R | |
| SCHEMBL9025720 | 0.86 | GHSR (0.70) | GHSRAGTR1XIAPNPY1R | |
| SCHEMBL9405635 | 0.86 | GHSR (0.67) | GHSRAGTR1XIAPNPY1R | |
| SCHEMBL8909523 | 0.85 | GHSR (0.64) | GHSRAGTR1XIAPNPY1R | |
| SCHEMBL9024349 | 0.85 | GHSR (0.68) | GHSRAGTR1XIAPNPY1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-H08506579-A | — | — | 1996-07-16 | — | — | JP | claimed |
| EP-0682654-A4 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE. | MERCK & CO INC (US) | 1996-01-17 | — | — | EP | claimed |
| EP-0682654-A1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO. INC. (US) | 1995-11-22 | — | — | EP | claimed |
| WO-1994018169-A1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO., INC. (US) | 1994-08-18 | — | — | WO | claimed |
| EP-0682654-A4 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE. | MERCK & CO INC (US) | 1996-01-17 | — | — | EP | disclosed |
| EP-0682654-A1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO. INC. (US) | 1995-11-22 | — | — | EP | disclosed |
| WO-1994018169-A1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO., INC. (US) | 1994-08-18 | — | — | WO | disclosed |
| US-5284841-A | Benzo-fused lactams promote release of growth hormone | MERCK & CO., INC. (US) | 1994-02-08 | — | — | US | disclosed |