Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GHSR | Q92847 | 4/20 | 0.55 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.55 |
| ▸ | XIAP | P98170 | 12/20 | 0.45 |
| ▸ | NPY1R | P25929 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| L-692585 SCHEMBL9024978 | 0.91 | GHSR (0.60) | GHSRAGTR1XIAP | |
| L-692585 SCHEMBL9025213 | 0.91 | GHSR (0.60) | GHSRAGTR1XIAP | |
| L-692585 SCHEMBL7474014 | 0.91 | GHSR (0.60) | GHSRAGTR1XIAP | |
| SCHEMBL1388282 | 0.90 | GHSR (0.68) | GHSRAGTR1XIAPNPY1R | |
| SCHEMBL9694520 | 0.87 | GHSR (0.53) | GHSRAGTR1XIAPNPY1R | |
| SCHEMBL8908983 | 0.87 | GHSR (0.52) | GHSRAGTR1XIAPNPY1R | |
| SCHEMBL9025440 | 0.86 | GHSR (0.61) | GHSRAGTR1XIAPNPY1R | |
| SCHEMBL1388243 | 0.86 | GHSR (0.59) | GHSRAGTR1XIAPNPY1R | |
| SCHEMBL9025110 | 0.86 | GHSR (0.59) | GHSRAGTR1XIAPNPY1R | |
| SCHEMBL9025740 | 0.86 | GHSR (0.59) | GHSRAGTR1XIAPNPY1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0682654-A4 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE. | MERCK & CO INC (US) | 1996-01-17 | — | — | EP | disclosed |
| EP-0682654-A1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO. INC. (US) | 1995-11-22 | — | — | EP | disclosed |
| WO-1994018169-A1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO., INC. (US) | 1994-08-18 | — | — | WO | disclosed |
| US-5284841-A | Benzo-fused lactams promote release of growth hormone | MERCK & CO., INC. (US) | 1994-02-08 | — | — | US | disclosed |