Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NQO2 | P16083 | 3/20 | 0.49 |
| ▸ | NQO1 | P15559 | 1/20 | 0.49 |
| ▸ | TUBB4A | P04350 | 4/20 | 0.44 |
| ▸ | TUBB | P07437 | 4/20 | 0.44 |
| ▸ | TUBA3C | P0DPH7 | 4/20 | 0.44 |
| ▸ | TUBA1B | P68363 | 4/20 | 0.44 |
| ▸ | TUBA4A | P68366 | 4/20 | 0.44 |
| ▸ | TUBB4B | P68371 | 4/20 | 0.44 |
| ▸ | TUBB3 | Q13509 | 4/20 | 0.44 |
| ▸ | TUBB2A | Q13885 | 4/20 | 0.44 |
| ▸ | TUBB8 | Q3ZCM7 | 4/20 | 0.44 |
| ▸ | TUBA3E | Q6PEY2 | 4/20 | 0.44 |
| ▸ | TUBA1A | Q71U36 | 4/20 | 0.44 |
| ▸ | TUBA1C | Q9BQE3 | 4/20 | 0.44 |
| ▸ | TUBB6 | Q9BUF5 | 4/20 | 0.44 |
| ▸ | TUBB2B | Q9BVA1 | 4/20 | 0.44 |
| ▸ | TUBB1 | Q9H4B7 | 4/20 | 0.44 |
| ▸ | ESR1 | P03372 | 2/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1388608 | 1.00 | NQO2 (0.49) | NQO2NQO1TUBB4ATUBBTUBA3C | |
| SCHEMBL11652104 | 0.78 | IMPDH2 (0.51) | NQO2NQO1TUBB4ATUBBTUBA3C | |
| SCHEMBL11822398 | 0.76 | MAPT (0.55) | NQO2NQO1TUBB4ATUBBTUBA3C | |
| SCHEMBL13485325 | 0.74 | KMT2A (0.59) | NQO2NQO1TUBB4ATUBBTUBA3C | |
| SCHEMBL13079421 | 0.74 | KDM4E (0.45) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL9095326 | 0.73 | MAPT (0.53) | NQO2NQO1MEN1KMT2AMAPT | |
| SCHEMBL9095321 | 0.73 | MAPT (0.53) | NQO2NQO1MEN1KMT2AMAPT | |
| SCHEMBL829252 | 0.72 | NQO2 (0.68) | NQO2NQO1TUBB4ATUBBTUBA3C | |
| SCHEMBL4990755 | 0.71 | ESR1 (0.64) | NQO2NQO1TUBB4ATUBBTUBA3C | |
| SCHEMBL4996056 | 0.71 | TUBB4A (0.80) | NQO2NQO1TUBB4ATUBBTUBA3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0987263-A2 | Arylidene and heteroarylidene oxindole derivatives as tyrosine kinase inhibitors | PHARMACIA & UPJOHN S.p.A. (IT) | 2000-03-22 | — | — | EP | claimed |
| JP-H08500847-A | — | — | 1996-01-30 | — | — | JP | claimed |
| EP-0658159-A1 | ARYLIDENE AND HETEROARYLIDENE OXINDOLE DERIVATIVES AS TYROSINE KINASE INHIBITORS | PHARMACIA & UPJOHN S.p.A. (IT) | 1995-06-21 | — | — | EP | claimed |
| WO-1995001349-A1 | ARYLIDENE AND HETEROARYLIDENE OXINDOLE DERIVATIVES AS TYROSINE KINASE INHIBITORS | PHARMACIA S.P.A. (IT) | 1995-01-12 | — | — | WO | claimed |
| EP-0987263-B1 | Arylidene and heteroarylidene oxindole derivatives as tyrosine kinase inhibitors | PFIZER ITALIA SRL (IT) | 2007-04-18 | — | — | EP | disclosed |
| EP-0987263-A2 | Arylidene and heteroarylidene oxindole derivatives as tyrosine kinase inhibitors | PHARMACIA & UPJOHN S.p.A. (IT) | 2000-03-22 | — | — | EP | disclosed |
| US-5656654-A | TYROSINE KINASE INHIBITORS | FARMITALIA CARLO ERBA S.R.L. (IT) | 1997-08-12 | — | — | US | disclosed |