Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.49 |
| ▸ | HPGD | P15428 | 6/20 | 0.49 |
| ▸ | GAA | P10253 | 5/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | FHIT | P49789 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | GRM6 | O15303 | 4/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13869918 | 0.88 | FHIT (0.41) | MAPTALDH1A1HPGDGAASMN1; SMN2 | |
| SCHEMBL13848533 | 0.81 | MAPT (0.49) | MAPTALDH1A1HPGDGAASMN1; SMN2 | |
| SCHEMBL3990334 | 0.80 | MAPT (0.51) | MAPTALDH1A1HPGDGAASMN1; SMN2 | |
| SCHEMBL19140015 | 0.79 | ALDH1A1 (0.48) | MAPTALDH1A1HPGDGAASMN1; SMN2 | |
| SCHEMBL2307828 | 0.76 | MAPT (0.60) | MAPTALDH1A1HPGDGAASMN1; SMN2 | |
| SCHEMBL6996573 | 0.74 | MAPT (0.57) | MAPTALDH1A1HPGDGAASMN1; SMN2 | |
| SCHEMBL24683238 | 0.73 | MAPT (0.57) | MAPTALDH1A1HPGDGAASMN1; SMN2 | |
| SCHEMBL21267971 | 0.72 | ALDH1A1 (0.54) | ALDH1A1HPGDGAATSHRMAPK1 | |
| SCHEMBL28281267 | 0.72 | SKP2 (0.55) | MAPTALDH1A1HPGDGAAALOX15 | |
| SCHEMBL3984848 | 0.72 | MAPT (0.67) | MAPTALDH1A1HPGDGAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7524853-B2 | Compounds and their use in therapy | SOLVAY PHARMACEUTICALS B.V. (NL) | 2009-04-28 | — | — | US | disclosed |