Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.49 |
| ▸ | GAA | P10253 | 7/20 | 0.49 |
| ▸ | MEN1 | O00255 | 5/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 5/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.49 |
| ▸ | HPGD | P15428 | 8/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.46 |
| ▸ | FHIT | P49789 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | CISD2 | Q8N5K1 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | GRM6 | O15303 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3990334 | 0.89 | MAPT (0.51) | MAPTGAAMEN1KMT2AALOX15 | |
| SCHEMBL13886791 | 0.81 | MAPT (0.49) | MAPTGAAMEN1KMT2AALOX15 | |
| SCHEMBL13869870 | 0.77 | MAPT (0.51) | MAPTGAAMEN1KMT2AALOX15 | |
| SCHEMBL3984848 | 0.75 | MAPT (0.67) | MAPTGAAMEN1KMT2AALOX15 | |
| SCHEMBL3982203 | 0.72 | MAPT (0.64) | MAPTGAAMEN1KMT2AALOX15 | |
| SCHEMBL3986612 | 0.71 | MAPT (0.52) | MAPTGAAMEN1KMT2AALOX15 | |
| SCHEMBL13869918 | 0.70 | FHIT (0.41) | MAPTGAATSHRALDH1A1HPGD | |
| SCHEMBL13848534 | 0.70 | MAPT (0.48) | MAPTGAAMEN1KMT2AALOX15 | |
| SCHEMBL223094 | 0.68 | ALDH1A1 (1.00) | MAPTGAAMEN1KMT2AALOX15 | |
| SCHEMBL24671856 | 0.68 | ALDH1A1 (0.68) | MAPTGAAMEN1KMT2AALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828197-B1 | NOVEL SUBSTITUTED THIOPHENEPYRIMIDINONE DERIVATIVES AS INHIBITORS OF 17ß-HYDROXYSTEROID DEHYDROGENASE | SOLVAY PHARM GMBH (DE) | 2009-05-13 | — | — | EP | disclosed |