Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 13/20 | 0.42 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.35 |
| ▸ | FPR1 | P21462 | 1/20 | 0.35 |
| ▸ | GPR183 | P32249 | 1/20 | 0.35 |
| ▸ | APLNR | P35414 | 1/20 | 0.35 |
| ▸ | GLP1R | P43220 | 1/20 | 0.35 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.35 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.35 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.34 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.34 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13891760 | 0.89 | TACR1 (0.41) | TACR1GRIN1GRIN2BROCK2ROCK1 | |
| SCHEMBL13891758 | 0.86 | TACR1 (0.41) | TACR1GRIN1GRIN2BROCK2ROCK1 | |
| SCHEMBL13891704 | 0.84 | PIK3R1 (0.46) | TACR1 | |
| SCHEMBL13891737 | 0.84 | TACR1 (0.41) | TACR1GRIN1GRIN2BROCK2ROCK1 | |
| SCHEMBL5229260 | 0.83 | TACR1 (0.41) | TACR1ROCK2ROCK1ADRB2FPR1 | |
| SCHEMBL6790261 | 0.82 | TACR1 (0.45) | TACR1GRIN1GRIN2BROCK2ROCK1 | |
| SCHEMBL5530949 | 0.80 | TACR1 (0.44) | TACR1GRIN1GRIN2BROCK2ROCK1 | |
| SCHEMBL6794955 | 0.79 | TACR1 (0.49) | TACR1GRIN1GRIN2BROCK2ROCK1 | |
| SCHEMBL14514053 | 0.79 | GRIN1 (0.40) | TACR1GRIN1GRIN2BROCK2ROCK1 | |
| SCHEMBL13891738 | 0.78 | TACR1 (0.41) | TACR1GRIN1GRIN2BROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1473295-B1 | FUSED BICYCLIC PYRIMIDINE DERIVATIVES | KYORIN SEIYAKU KK (JP) | 2009-04-01 | — | — | EP | disclosed |