Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 5/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.36 |
| ▸ | WDR5 | P61964 | 5/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | TNIK | Q9UKE5 | 2/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
| ▸ | FPR1 | P21462 | 1/20 | 0.33 |
| ▸ | GPR183 | P32249 | 1/20 | 0.33 |
| ▸ | APLNR | P35414 | 1/20 | 0.33 |
| ▸ | GLP1R | P43220 | 1/20 | 0.33 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.33 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13891760 | 0.90 | TACR1 (0.41) | TACR1ROCK2ROCK1GRIN1GRIN2B | |
| SCHEMBL13891759 | 0.87 | TACR1 (0.37) | TACR1WDR5ROCK2ROCK1TNIK | |
| SCHEMBL13891758 | 0.84 | TACR1 (0.41) | TACR1ROCK2ROCK1GRIN1GRIN2B | |
| SCHEMBL13891713 | 0.84 | TACR1 (0.42) | TACR1ROCK2ROCK1TNIKGRIN1 | |
| SCHEMBL13891686 | 0.78 | MAPT (0.35) | P2RX7 | |
| SCHEMBL13891705 | 0.78 | MTOR (0.38) | TACR1ROCK2ROCK1TNIKADRB2 | |
| SCHEMBL13891719 | 0.76 | TACR1 (0.48) | TACR1ROCK2ROCK1 | |
| SCHEMBL13891718 | 0.75 | TACR1 (0.40) | TACR1ROCK2ROCK1GRIN1GRIN2B | |
| SCHEMBL13891738 | 0.75 | TACR1 (0.41) | TACR1ROCK2ROCK1TNIKGRIN1 | |
| SCHEMBL5229635 | 0.75 | TACR1 (0.41) | TACR1ADRB2FPR1GPR183APLNR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1473295-B1 | FUSED BICYCLIC PYRIMIDINE DERIVATIVES | KYORIN SEIYAKU KK (JP) | 2009-04-01 | — | — | EP | disclosed |