Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3R1 | P27986 | 6/20 | 0.46 |
| ▸ | MTOR | P42345 | 6/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | TACR1 | P25103 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | CASP1 | P29466 | 2/20 | 0.37 |
| ▸ | CASP5 | P51878 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13891619 | 0.92 | MTOR (0.47) | PIK3R1MTORTACR1LMNATSHR | |
| SCHEMBL13891741 | 0.89 | MTOR (0.46) | PIK3R1MTORTACR1PIK3CACASP1 | |
| SCHEMBL13891717 | 0.89 | ADRB2 (0.43) | PIK3R1MTORNPSR1ATMTDP1 | |
| SCHEMBL13891764 | 0.88 | PIK3R1 (0.38) | PIK3R1MTORNPSR1ATMTDP1 | |
| SCHEMBL13891705 | 0.85 | MTOR (0.38) | PIK3R1MTORTACR1PIK3CACASP1 | |
| SCHEMBL13891713 | 0.84 | TACR1 (0.42) | TACR1 | |
| SCHEMBL13891687 | 0.82 | PIK3R1 (0.41) | PIK3R1MTORTDP1L3MBTL1TACR1 | |
| SCHEMBL13891719 | 0.79 | TACR1 (0.48) | TACR1CASP1CASP5 | |
| SCHEMBL5530949 | 0.79 | TACR1 (0.44) | TACR1 | |
| SCHEMBL6790261 | 0.79 | TACR1 (0.45) | TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1473295-B1 | FUSED BICYCLIC PYRIMIDINE DERIVATIVES | KYORIN SEIYAKU KK (JP) | 2009-04-01 | — | — | EP | disclosed |