Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDO2 | P48775 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.42 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.42 |
| ▸ | VHL | P40337 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MGAM | O43451 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | SI | P14410 | 1/20 | 0.38 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.38 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | SCD | O00767 | 1/20 | 0.37 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.36 |
| ▸ | MPL | P40238 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28231982 | 0.79 | KDM4E (0.50) | TDO2NPC1VHLKDM4EGAA | |
| SCHEMBL13141588 | 0.79 | PDE5A (0.41) | NPC1CASP3SENP8SENP7SENP6 | |
| SCHEMBL13141590 | 0.78 | GABRG2 (0.43) | TDO2NPC1CASP3SENP8SENP7 | |
| SCHEMBL27741609 | 0.76 | MAP4K1 (0.46) | NPC1CASP3SENP8SENP7SENP6 | |
| SCHEMBL11695271 | 0.75 | TDO2 (0.46) | TDO2VHL | |
| SCHEMBL27741619 | 0.73 | DCUN1D1 (0.45) | NPC1CASP3SENP8SENP7SENP6 | |
| SCHEMBL8784700 | 0.73 | GAA (0.47) | NPC1L3MBTL1MGAMGAASI | |
| SCHEMBL7372676 | 0.72 | NPC1 (0.52) | TDO2NPC1KDM4EGAARAB9A | |
| SCHEMBL8629915 | 0.71 | PDGFRB (0.36) | NPC1CASP3SENP8SENP7SENP6 | |
| SCHEMBL29662748 | 0.71 | CSNK1D (0.48) | NPC1CASP3SENP8SENP7SENP6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009051705-A1 | SUBSTITUTED 1,2,4-OXADIAZOLES AND ANALOGS THEREOF AS CB2 RECEPTOR MODULATORS, USEFUL IN THE TREATMENT OF PAIN, RESPIRATORY AND NON-RESPIRATORY DISEASES | MERCK & CO., INC. (US) | 2009-04-23 | — | — | WO | disclosed |