Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHPS | P49366 | 6/20 | 0.51 |
| ▸ | BTK | Q06187 | 3/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.43 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.43 |
| ▸ | F10 | P00742 | 1/20 | 0.42 |
| ▸ | TMIGD3 | P0DMS9 | 2/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.41 |
| ▸ | STAT1 | P42224 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13893940 | 0.82 | BTK (0.53) | BTKALDH1A1LMNA | |
| SCHEMBL13894283 | 0.78 | BTK (0.53) | BTKHDAC1HDAC2 | |
| SCHEMBL171471 | 0.78 | BTK (0.67) | DHPSBTKALDH1A1 | |
| SCHEMBL1038028 | 0.76 | BTK (0.49) | DHPSBTK | |
| SCHEMBL13894036 | 0.75 | ITK (0.54) | BTKHDAC1ALDH1A1LMNA | |
| SCHEMBL12663172 | 0.74 | HDAC2 (0.70) | DHPSHDAC1HDAC2HDAC3HDAC4 | |
| SCHEMBL105874 | 0.73 | BTK (0.54) | DHPSBTKHDAC1ALDH1A1LMNA | |
| SCHEMBL13894035 | 0.73 | TAS1R3 (0.50) | HDAC1HDAC2 | |
| SCHEMBL171444 | 0.72 | BTK (0.45) | BTKALDH1A1LMNA | |
| SCHEMBL30050486 | 0.71 | HDAC2 (0.54) | DHPSHDAC1HDAC2HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009053269-A1 | NOVEL KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-04-30 | — | — | WO | disclosed |