Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 17/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | BMX | P51813 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13893940 | 0.90 | BTK (0.53) | BTKEGFRBMXJAK3NPC1 | |
| SCHEMBL1203898 | 0.74 | BTK (0.69) | BTKEGFRBMXJAK3 | |
| SCHEMBL171447 | 0.73 | BTK (0.54) | BTKBMXNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1322768 | 0.73 | BTK (0.52) | BTKNPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL3956979 | 0.72 | BTK (0.47) | BTKNPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL3346426 | 0.72 | BTK (0.64) | BTK | |
| SCHEMBL13893955 | 0.72 | DHPS (0.51) | BTKALDH1A1LMNA | |
| SCHEMBL3969273 | 0.71 | BTK (0.46) | BTKNPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL1321976 | 0.71 | BTK (0.57) | BTKEGFRBMXJAK3 | |
| SCHEMBL12956112 | 0.70 | BTK (0.52) | BTKEGFRBMXJAK3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2426109-A1 | NOVEL KINASE INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2012-03-07 | — | — | EP | disclosed |