Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 19/20 | 0.61 |
| ▸ | ITK | Q08881 | 2/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | LYN | P07948 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | TEC | P42680 | 1/20 | 0.39 |
| ▸ | TXK | P42681 | 1/20 | 0.39 |
| ▸ | BLK | P51451 | 1/20 | 0.39 |
| ▸ | BMX | P51813 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.39 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL108070 | 0.76 | BTK (1.00) | BTKITKJAK2NTRK1LCK | |
| SCHEMBL8735247 | 0.76 | BTK (0.76) | BTKJAK2 | |
| SCHEMBL13893949 | 0.71 | ITK (0.57) | BTKITKSRC | |
| SCHEMBL13894298 | 0.66 | ITK (0.45) | BTKITKSRC | |
| SCHEMBL13894290 | 0.65 | ITK (0.58) | BTKITKSRCBMX | |
| SCHEMBL13894037 | 0.65 | ITK (0.50) | BTKITKSRCKCNH2 | |
| SCHEMBL17699541 | 0.64 | BTK (1.00) | BTKITKJAK2NTRK1LCK | |
| SCHEMBL29782619 | 0.64 | BTK (1.00) | BTKITKJAK2NTRK1LCK | |
| SCHEMBL13894019 | 0.64 | KDM4E (0.40) | BTKJAK2 | |
| SCHEMBL13894049 | 0.63 | BTK (0.43) | BTKITKSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009053269-A1 | NOVEL KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-04-30 | — | — | WO | disclosed |