Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 9/20 | 0.58 |
| ▸ | KIT | P10721 | 4/20 | 0.58 |
| ▸ | SRC | P12931 | 4/20 | 0.58 |
| ▸ | FLT3 | P36888 | 4/20 | 0.58 |
| ▸ | BTK | Q06187 | 8/20 | 0.47 |
| ▸ | TTK | P33981 | 2/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.43 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | BMX | P51813 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13893949 | 0.90 | ITK (0.57) | ITKKITSRCFLT3BTK | |
| SCHEMBL13894298 | 0.86 | ITK (0.45) | ITKKITSRCFLT3BTK | |
| SCHEMBL13894036 | 0.86 | ITK (0.54) | ITKKITSRCFLT3BTK | |
| SCHEMBL13894052 | 0.83 | ITK (0.47) | ITKKITSRCFLT3BTK | |
| SCHEMBL106046 | 0.82 | BTK (0.64) | BTKEGFRBMXJAK3 | |
| SCHEMBL13894049 | 0.80 | BTK (0.43) | ITKKITSRCFLT3BTK | |
| SCHEMBL13894122 | 0.79 | ITK (0.54) | ITKKITSRCFLT3BTK | |
| SCHEMBL13894037 | 0.78 | ITK (0.50) | ITKKITSRCFLT3BTK | |
| SCHEMBL3870962 | 0.77 | BTK (0.70) | ITKKITSRCFLT3BTK | |
| SCHEMBL4080570 | 0.77 | BTK (0.52) | ITKKITSRCFLT3BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009053269-A1 | NOVEL KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-04-30 | — | — | WO | disclosed |