Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 11/20 | 0.57 |
| ▸ | BTK | Q06187 | 2/20 | 0.50 |
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
| ▸ | TTK | P33981 | 3/20 | 0.46 |
| ▸ | AURKA | O14965 | 2/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.46 |
| ▸ | INCENP | Q9NQS7 | 2/20 | 0.46 |
| ▸ | KIT | P10721 | 5/20 | 0.45 |
| ▸ | SRC | P12931 | 5/20 | 0.45 |
| ▸ | FLT3 | P36888 | 5/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13894290 | 0.90 | ITK (0.58) | ITKBTKTTKAURKAAURKB | |
| SCHEMBL13894052 | 0.86 | ITK (0.47) | ITKBTKTTKAURKAAURKB | |
| SCHEMBL13894283 | 0.85 | BTK (0.53) | ITKBTKPARP1TTKAURKA | |
| SCHEMBL13894298 | 0.84 | ITK (0.45) | ITKBTKTTKAURKAAURKB | |
| SCHEMBL13894049 | 0.83 | BTK (0.43) | ITKBTKTTKAURKAAURKB | |
| SCHEMBL13894037 | 0.81 | ITK (0.50) | ITKBTKTTKAURKAAURKB | |
| SCHEMBL3870962 | 0.81 | BTK (0.70) | ITKBTKKITSRCFLT3 | |
| SCHEMBL13894045 | 0.80 | RAB9A (0.45) | ITKBTKPARP1MAPTTP53 | |
| SCHEMBL171935 | 0.79 | BTK (0.59) | ITKBTKKITSRCFLT3 | |
| SCHEMBL171471 | 0.76 | BTK (0.67) | ITKBTKKITSRCFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009053269-A1 | NOVEL KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-04-30 | — | — | WO | disclosed |