Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 2/20 | 0.58 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | PHGDH | O43175 | 6/20 | 0.47 |
| ▸ | EIF4A3 | P38919 | 1/20 | 0.45 |
| ▸ | GFER | P55789 | 2/20 | 0.44 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.41 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | DAO | P14920 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9613270 | 0.87 | HSD17B10 (0.62) | MCL1GPR35HSD17B10KDM4EALDH1A1 | |
| SCHEMBL13889409 | 0.87 | MCL1 (0.42) | MCL1GPR35HSD17B10KDM4EALDH1A1 | |
| SCHEMBL30790917 | 0.87 | HSD17B10 (0.62) | MCL1GPR35HSD17B10KDM4EALDH1A1 | |
| SCHEMBL13895694 | 0.86 | SLC9A1 (0.42) | MCL1GPR35HSD17B10KDM4EALDH1A1 | |
| SCHEMBL6755414 | 0.85 | MCL1 (0.53) | MCL1GPR35HSD17B10KDM4EALDH1A1 | |
| SCHEMBL3061835 | 0.78 | MCL1 (0.64) | MCL1GPR35HSD17B10KDM4EALDH1A1 | |
| SCHEMBL10254076 | 0.78 | MCL1 (0.64) | MCL1GPR35HSD17B10KDM4EALDH1A1 | |
| SCHEMBL13677503 | 0.78 | HTR7 (0.38) | ALDH1A1SMN1; SMN2PHGDHEIF4A3 | |
| SCHEMBL2828847 | 0.77 | MCL1 (0.62) | MCL1GPR35HSD17B10KDM4EALDH1A1 | |
| SCHEMBL31623397 | 0.77 | MCL1 (0.62) | MCL1GPR35HSD17B10KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012155066-A2 | SPIRO-OXINDOLE MDM2 ANTAGONISTS | WANG SHAOMENG (US) | 2012-11-15 | — | — | WO | disclosed |