Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC9A1 | P19634 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.41 |
| ▸ | PHGDH | O43175 | 5/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.38 |
| ▸ | EIF4A3 | P38919 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | TYR | P14679 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12894673 | 0.88 | KDM4E (0.45) | SLC9A1MCL1PHGDHRXFP1JAK2 | |
| SCHEMBL30547733 | 0.88 | KDM4E (0.45) | SLC9A1MCL1PHGDHRXFP1JAK2 | |
| SCHEMBL13895693 | 0.86 | MCL1 (0.58) | MCL1PHGDHTP53RXFP1GPR35 | |
| SCHEMBL13889409 | 0.86 | MCL1 (0.42) | SLC9A1MCL1PHGDHTP53RXFP1 | |
| SCHEMBL16480591 | 0.79 | PLA2G10 (0.48) | SLC9A1MCL1TP53RXFP1GPR35 | |
| SCHEMBL2323444 | 0.75 | MCL1 (0.71) | SLC9A1MCL1PHGDHMAPT | |
| Hydrochloric Acid SCHEMBL28264080 | 0.73 | MCL1 (0.69) | SLC9A1MCL1MAPT | |
| SCHEMBL9613270 | 0.73 | HSD17B10 (0.62) | MCL1PHGDHGPR35ALDH1A1KDM4E | |
| SCHEMBL13881405 | 0.73 | KDM4E (0.46) | MCL1PHGDHTP53RXFP1GPR35 | |
| SCHEMBL30790917 | 0.73 | HSD17B10 (0.62) | MCL1PHGDHGPR35ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012155066-A2 | SPIRO-OXINDOLE MDM2 ANTAGONISTS | WANG SHAOMENG (US) | 2012-11-15 | — | — | WO | disclosed |