Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G10 | O15496 | 2/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | SLC9A1 | P19634 | 2/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.41 |
| ▸ | CCR9 | P51686 | 1/20 | 0.41 |
| ▸ | KMO | O15229 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9613264 | 0.86 | THRB (0.61) | PLA2G10THRBMCL1LMNARXFP1 | |
| SCHEMBL10254076 | 0.84 | MCL1 (0.64) | THRBMCL1LMNARXFP1TP53 | |
| SCHEMBL7881270 | 0.80 | L3MBTL1 (0.59) | THRBMCL1LMNARXFP1TP53 | |
| SCHEMBL13895694 | 0.79 | SLC9A1 (0.42) | SLC9A1MCL1RXFP1TP53MAPT | |
| SCHEMBL19345900 | 0.79 | GPR35 (0.47) | THRBSLC9A1MCL1LMNARXFP1 | |
| SCHEMBL2323444 | 0.79 | MCL1 (0.71) | PLA2G10SLC9A1MCL1MAPTMEN1 | |
| Hydrochloric Acid SCHEMBL28264080 | 0.77 | MCL1 (0.69) | PLA2G10SLC9A1MCL1MAPTMEN1 | |
| SCHEMBL28204879 | 0.74 | PLA2G10 (0.54) | PLA2G10MCL1L3MBTL1 | |
| SCHEMBL327069 | 0.73 | MCL1 (0.63) | PLA2G10SLC9A1MCL1MAPTGPR35 | |
| SCHEMBL3341263 | 0.73 | SLC9A1 (0.43) | PLA2G10SLC9A1MCL1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8629141-B2 | Spiro-oxindole MDM2 antagonists | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2014-01-14 | — | — | US | disclosed |