Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | DRD2 | P14416 | 3/20 | 0.43 |
| ▸ | KDM1A | O60341 | 6/20 | 0.43 |
| ▸ | TLR2 | O60603 | 2/20 | 0.43 |
| ▸ | TLR1 | Q15399 | 2/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3896702 | 1.00 | LMNA (0.58) | LMNASMN1; SMN2TSHRDRD2KDM1A | |
| SCHEMBL7465842 | 0.83 | DRD4 (0.46) | DRD2KDM1ATLR2TLR1MAOA | |
| SCHEMBL13898533 | 0.83 | LMNA (0.48) | LMNASMN1; SMN2KDM1AMAOBKDM4E | |
| SCHEMBL3902533 | 0.79 | SMN1; SMN2 (0.62) | LMNASMN1; SMN2TSHRDRD2KDM4E | |
| SCHEMBL3900031 | 0.79 | DRD2 (0.56) | SMN1; SMN2DRD2 | |
| SCHEMBL3900030 | 0.79 | DRD2 (0.56) | SMN1; SMN2DRD2 | |
| SCHEMBL3888734 | 0.77 | DRD2 (0.60) | SMN1; SMN2TSHRDRD2 | |
| SCHEMBL3893619 | 0.74 | SMN1; SMN2 (0.61) | LMNASMN1; SMN2TSHRDRD2KDM4E | |
| SCHEMBL3891434 | 0.73 | OPRL1 (0.71) | SMN1; SMN2DRD2ALDH1A1 | |
| SCHEMBL17001402 | 0.71 | KDM1A (0.72) | KDM1AMAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7498344-B2 | Arylpiperidinol and arylpiperidine derivatives and pharmaceuticals containing the same | ASUBIO PHARMA CO., LTD. (JP) | 2009-03-03 | — | — | US | disclosed |
| US-7498344-B2 | Arylpiperidinol and arylpiperidine derivatives and pharmaceuticals containing the same | ASUBIO PHARMA CO., LTD. (JP) | 2009-03-03 | — | — | US | disclosed |