Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.55 |
| ▸ | PKM | P14618 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.53 |
| ▸ | TSHR | P16473 | 3/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.50 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.50 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.50 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13899493 | 0.86 | TSHR (0.59) | LMNAPKMKDM4ETSHRCYP3A4 | |
| SCHEMBL5324874 | 0.84 | LMNA (0.55) | LMNAPKMKDM4ETSHRCYP3A4 | |
| SCHEMBL14188814 | 0.82 | MAPT (0.48) | LMNAPKMKDM4ETSHRCYP3A4 | |
| SCHEMBL5327176 | 0.82 | LMNA (0.47) | LMNAPKMKDM4ETSHRCYP3A4 | |
| SCHEMBL201295 | 0.79 | LMNA (0.51) | LMNAPKMKDM4ETSHRCYP3A4 | |
| SCHEMBL29255201 | 0.78 | PKM (0.39) | LMNAPKMKDM4ETSHRCYP3A4 | |
| SCHEMBL29254867 | 0.78 | LMNA (0.46) | LMNAPKMTSHRCYP3A4MAPT | |
| SCHEMBL24701303 | 0.76 | CYP3A4 (0.48) | LMNAPKMKDM4ETSHRCYP3A4 | |
| SCHEMBL12509518 | 0.74 | KDM4E (0.47) | LMNAPKMKDM4ETSHRCYP3A4 | |
| SCHEMBL13899484 | 0.74 | LMNA (0.48) | LMNAPKMKDM4ETSHRCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7507757-B2 | Substituted heterocyclic derivatives useful as antidiabetic and antiobesity agents and method | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-03-24 | — | — | US | disclosed |