Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | GID4 | Q8IVV7 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MPO | P05164 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.40 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13906078 | 0.92 | LMNA (0.47) | LMNAPKMKDM4EALDH1A1CYP3A4 | |
| SCHEMBL13899490 | 0.91 | LMNA (0.47) | LMNAPKMKDM4EALDH1A1CYP3A4 | |
| SCHEMBL13899481 | 0.89 | LMNA (0.46) | LMNAPKMKDM4EALDH1A1CYP3A4 | |
| SCHEMBL13899509 | 0.89 | LMNA (0.46) | LMNAPKMKDM4EALDH1A1CYP3A4 | |
| SCHEMBL13899497 | 0.80 | PPARG (0.49) | LMNAPKMKDM4EALDH1A1CYP3A4 | |
| SCHEMBL13899510 | 0.79 | PPARG (0.46) | LMNAPKMKDM4EALDH1A1CYP3A4 | |
| SCHEMBL3498807 | 0.78 | BCHE (0.67) | GID4SMN1; SMN2BCHEMEN1KMT2A | |
| SCHEMBL13899485 | 0.76 | KDM4E (0.47) | LMNAPKMKDM4EALDH1A1CYP3A4 | |
| SCHEMBL13899486 | 0.74 | LMNA (0.55) | LMNAPKMKDM4EALDH1A1CYP3A4 | |
| SCHEMBL13899335 | 0.73 | LPAR1 (0.41) | LMNAPKMKDM4EALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7507757-B2 | Substituted heterocyclic derivatives useful as antidiabetic and antiobesity agents and method | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-03-24 | — | — | US | disclosed |