Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 4/20 | 0.68 |
| ▸ | BCHE | P06276 | 4/20 | 0.58 |
| ▸ | ALB | P02768 | 3/20 | 0.58 |
| ▸ | ACHE | P22303 | 2/20 | 0.58 |
| ▸ | BRD2 | P25440 | 1/20 | 0.52 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.52 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7286323 | 0.81 | BRD4 (0.47) | BRD4BCHEALBACHE | |
| SCHEMBL1391 | 0.80 | BRD4 (0.64) | BRD4BCHEALBACHEBRD2 | |
| SCHEMBL588 | 0.77 | BCHE (0.69) | BRD4BCHEALBACHEBRD2 | |
| Hydrochloric Acid SCHEMBL31078359 | 0.74 | HDAC1 (0.49) | BRD4 | |
| SCHEMBL12216223 | 0.73 | DHFR (0.61) | ACHE | |
| SCHEMBL1268 | 0.72 | BCHE (0.62) | BRD4BCHEALBACHEBRD2 | |
| SCHEMBL17302647 | 0.72 | BRD4 (0.74) | BRD4BCHEALBACHEBRD2 | |
| SCHEMBL7140681 | 0.72 | NPC1 (0.53) | ACHE | |
| SCHEMBL918 | 0.72 | BRD4 (0.57) | BRD4BCHEALBACHEBRD2 | |
| SCHEMBL9837125 | 0.71 | CYP3A4 (0.74) | BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5360800-A | Tetrahydro-1H-pyrido[4,3-b]indol-1-one derivatives | GLAXO GROUP LIMITED (GB) | 1994-11-01 | — | — | US | disclosed |
| EP-0306323-B1 | Lactam derivatives | GLAXO GROUP LTD (GB) | 1994-09-21 | — | — | EP | disclosed |
| EP-0306323-A2 | Lactam derivatives | GLAXO GROUP LIMITED (GB) | 1989-03-08 | — | — | EP | disclosed |