Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | CNR2 | P34972 | 3/20 | 0.51 |
| ▸ | CNR1 | P21554 | 2/20 | 0.51 |
| ▸ | ACHE | P22303 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.47 |
| ▸ | RORC | P51449 | 2/20 | 0.47 |
| ▸ | RORA | P35398 | 1/20 | 0.47 |
| ▸ | RORB | Q92753 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | DHFR | P00374 | 1/20 | 0.46 |
| ▸ | CRY1 | Q16526 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19179039 | 0.94 | CYP1A2 (0.50) | NPC1KDM4EALDH1A1NPSR1HSD17B10 | |
| SCHEMBL5795412 | 0.90 | CYP1A2 (0.54) | NPC1KDM4EALDH1A1NPSR1HSD17B10 | |
| SCHEMBL12216223 | 0.90 | DHFR (0.61) | NPC1KDM4EALDH1A1NPSR1HSD17B10 | |
| SCHEMBL12469831 | 0.85 | NPC1 (0.52) | NPC1KDM4EALDH1A1NPSR1HSD17B10 | |
| SCHEMBL4779304 | 0.83 | PTGER4 (0.54) | NPC1KDM4EALDH1A1NPSR1HSD17B10 | |
| SCHEMBL22441902 | 0.81 | PTGER4 (0.45) | NPC1KDM4EALDH1A1NPSR1HSD17B10 | |
| SCHEMBL22441906 | 0.81 | PTGER4 (0.43) | NPC1KDM4EALDH1A1NPSR1HSD17B10 | |
| SCHEMBL5260181 | 0.80 | NPC1 (0.50) | NPC1KDM4EALDH1A1NPSR1HSD17B10 | |
| SCHEMBL17805941 | 0.79 | ADRA2A (0.43) | NPC1CNR2CYP1A2CYP2C19ADRA2A | |
| SCHEMBL17938383 | 0.78 | PTGER4 (0.56) | NPC1KDM4ECNR2CNR1RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6525043-B2 | Bicyclic or tricyclic ketones, oximes, amine oxides or amines are used as calcium or potassium channel modulators | NEUROSEARCH A/S (DK) | 2003-02-25 | — | — | US | claimed |
| US-20020065266-A1 | Use of ion channel modulating agents | NEUROSEARCH A/S (DK) | 2002-05-30 | — | — | US | claimed |
| EP-1187610-A2 | USE OF ION CHANNEL MODULATING AGENTS | NEUROSEARCH A/S (DK) | 2002-03-20 | — | — | EP | claimed |
| WO-2000069794-A2 | USE OF CALCIUM-ACTIVATED POTASSIUM CHANNEL-MODULATING AGENTS | NEUROSEARCH A/S (DK) | 2000-11-23 | — | — | WO | claimed |
| US-11912699-B2 | Tau-protein targeting compounds and associated | ARVINAS OPERATIONS, INC. (US) | 2024-02-27 | — | — | US | disclosed |
| US-20230270763-A1 | METHOD OF TREATING CORONOVIRUS INFECTIONS WITH CANNABINOIDS AND DERIVATIVES | PASCAL BIOSCIENCES INC (CA) | 2023-08-31 | — | — | US | disclosed |
| US-6525043-B2 | Bicyclic or tricyclic ketones, oximes, amine oxides or amines are used as calcium or potassium channel modulators | NEUROSEARCH A/S (DK) | 2003-02-25 | — | — | US | disclosed |
| US-6525228-B2 | Reacting a conjugated diene with a compound containing active hydrogen in the presence of a cataylst system comprising a transition metal compound, a phosphorus containing compound and atleast one salt | CELANESE CHEMICALS EUROPE GMBH (DE) | 2003-02-25 | — | — | US | disclosed |
| US-20020091281-A1 | Process of telomerizing conjugated dienes | CELANESE CHEMICALS EUROPE GMBH (DE) | 2002-07-11 | — | — | US | disclosed |
| US-20020065266-A1 | Use of ion channel modulating agents | NEUROSEARCH A/S (DK) | 2002-05-30 | — | — | US | disclosed |
| EP-1187610-A2 | USE OF ION CHANNEL MODULATING AGENTS | NEUROSEARCH A/S (DK) | 2002-03-20 | — | — | EP | disclosed |
| WO-2000069794-A2 | USE OF CALCIUM-ACTIVATED POTASSIUM CHANNEL-MODULATING AGENTS | NEUROSEARCH A/S (DK) | 2000-11-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11912699-B2 | Tau-protein targeting compounds and associated | MAPT, VHL, CRBN | NPC1 2550/4885KDM4E 1112/4885ALDH1A1 3804/4885 |
| US-20020065266-A1 | Use of ion channel modulating agents | KCNN3, KCNN1, KCNN2 | NPC1 1403/4885KDM4E 1513/4885ALDH1A1 4532/4885 |
| US-20230270763-A1 | METHOD OF TREATING CORONOVIRUS INFECTIONS WITH CANNABINOIDS AND DERIVATIVES | CNR1, CNR2, SARS1 | NPC1 938/4885KDM4E 1163/4885ALDH1A1 3300/4885 |
| US-20020091281-A1 | Process of telomerizing conjugated dienes | TELO2, TERT, PCNA | NPC1 3896/4885KDM4E 2056/4885ALDH1A1 3298/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.