Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | PHGDH | O43175 | 1/20 | 0.44 |
| ▸ | MGLL | Q99685 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | DPP4 | P27487 | 5/20 | 0.42 |
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.42 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16435174 | 0.82 | ALDH1A1 (0.61) | ALDH1A1MEN1KMT2ANPC1PHGDH | |
| SCHEMBL15247299 | 0.82 | CYP2C19 (0.49) | ALDH1A1MEN1KMT2ACYP2C19DPP4 | |
| SCHEMBL16368739 | 0.82 | ALDH1A1 (0.61) | ALDH1A1MEN1KMT2ANPC1PHGDH | |
| SCHEMBL4057803 | 0.82 | GNAI3 (0.47) | ALDH1A1MEN1KMT2ACYP2C19DPP4 | |
| SCHEMBL13901222 | 0.82 | EPHX2 (0.51) | ALDH1A1MEN1KMT2ACYP2C19DPP4 | |
| SCHEMBL8342259 | 0.79 | EPHX2 (0.48) | ALDH1A1MEN1KMT2ACYP2C19DPP4 | |
| SCHEMBL20746935 | 0.79 | ALDH1A1 (0.49) | ALDH1A1MEN1KMT2ANPC1HPGD | |
| SCHEMBL13266483 | 0.79 | CYP2C19 (0.51) | ALDH1A1MEN1KMT2ACYP2C19HPGD | |
| SCHEMBL17546274 | 0.78 | ALDH1A1 (0.56) | ALDH1A1MEN1KMT2ANPC1PHGDH | |
| SCHEMBL22698942 | 0.78 | CYP2C19 (0.42) | ALDH1A1MEN1KMT2ACYP2C19DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7511144-B2 | Reverse hydroxamic acid derivatives | KAKEN PHARMACEUTICAL CO., LTD. (JP) | 2009-03-31 | — | — | US | disclosed |
| US-7511144-B2 | Reverse hydroxamic acid derivatives | KAKEN PHARMACEUTICAL CO., LTD. (JP) | 2009-03-31 | — | — | US | disclosed |
| EP-1431285-B1 | REVERSE HYDROXAMIC ACID DERIVATIVES | KAKEN PHARMA CO LTD (JP) | 2009-01-07 | — | — | EP | disclosed |