Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | DPP4 | P27487 | 6/20 | 0.48 |
| ▸ | DPP8 | Q6V1X1 | 4/20 | 0.48 |
| ▸ | DPP7 | Q9UHL4 | 4/20 | 0.48 |
| ▸ | DPP9 | Q86TI2 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PHGDH | O43175 | 1/20 | 0.39 |
| ▸ | MGLL | Q99685 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17540494 | 0.86 | DPP4 (0.45) | ALDH1A1MEN1KMT2ADPP4DPP8 | |
| SCHEMBL17546275 | 0.82 | ALDH1A1 (0.63) | ALDH1A1MEN1KMT2ANPC1HPGD | |
| SCHEMBL16368739 | 0.80 | ALDH1A1 (0.61) | ALDH1A1MEN1KMT2ADPP4DPP8 | |
| SCHEMBL16435174 | 0.80 | ALDH1A1 (0.61) | ALDH1A1MEN1KMT2ADPP4DPP8 | |
| SCHEMBL13901271 | 0.78 | ALDH1A1 (0.58) | ALDH1A1MEN1KMT2ADPP4DPP8 | |
| SCHEMBL13438120 | 0.77 | ALDH1A1 (0.68) | ALDH1A1MEN1KMT2ANPC1HPGD | |
| SCHEMBL2606047 | 0.75 | ALDH1A1 (0.70) | ALDH1A1MEN1KMT2ANPC1HPGD | |
| SCHEMBL10280123 | 0.73 | ALDH1A1 (0.56) | ALDH1A1MEN1KMT2ANPC1HPGD | |
| SCHEMBL10328273 | 0.73 | ALDH1A1 (0.56) | ALDH1A1MEN1KMT2ANPC1HPGD | |
| SCHEMBL14417829 | 0.73 | ALDH1A1 (0.56) | ALDH1A1MEN1KMT2ANPC1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170233371-A1 | RORC2 INHIBITORS AND METHODS OF USE THEREOF | PFIZER INC. (US) | 2017-08-17 | — | — | US | disclosed |
| US-20160046597-A1 | RORC2 INHIBITORS AND METHODS OF USE THEREOF | PFIZER (US) | 2016-02-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160046597-A1 | RORC2 INHIBITORS AND METHODS OF USE THEREOF | RORC, RORB, RORA | ALDH1A1 576/4885MEN1 3968/4885KMT2A 1687/4885 |
| US-20170233371-A1 | RORC2 INHIBITORS AND METHODS OF USE THEREOF | RORC, RORB, RORA | ALDH1A1 576/4885MEN1 3968/4885KMT2A 1687/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.