Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 6/20 | 0.40 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.40 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 5/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.38 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2244348 | 0.89 | SYK (0.41) | SYKALOX5APCYP19A1KDM4EALDH1A1 | |
| SCHEMBL2248075 | 0.87 | ALOX5AP (0.39) | SYKPARP10ALOX5APCYP19A1KDM4E | |
| SCHEMBL13248369 | 0.84 | KDM4C (0.47) | PARP10ALOX5APALDH1A1ADAMTS4CYP2C9 | |
| SCHEMBL13248546 | 0.79 | PARP10 (0.49) | SYKPARP10ALOX5APKDM4EALDH1A1 | |
| SCHEMBL2246846 | 0.78 | NPC1 (0.53) | SYKPARP10ALOX5APCYP19A1KDM4E | |
| SCHEMBL2994531 | 0.78 | ALOX5AP (0.49) | SYKPARP10ALOX5APKDM4EALDH1A1 | |
| SCHEMBL2245019 | 0.78 | NPC1 (0.47) | PARP10SMN1; SMN2CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL2242925 | 0.77 | ADAMTS4 (0.42) | SYKCYP19A1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL2246698 | 0.77 | DHODH (0.41) | SYKPARP10ALOX5APKDM4EALDH1A1 | |
| SCHEMBL2990181 | 0.77 | MAPK14 (0.54) | SYKPARP10ALOX5APKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2546232-A1 | Diphenyl Substituted Alkanes | Merck Sharp & Dohme Corp. (US) | 2013-01-16 | — | — | EP | disclosed |
| EP-1814877-B1 | DIPHENYL SUBSTITUTED ALKANES AS FLAP INHIBITORS | MERCK & CO INC (US) | 2009-03-11 | — | — | EP | disclosed |
| WO-2008156721-A1 | DIPHENYL SUBSTITUTED ALKANES | MERCK & CO., INC. (US) | 2008-12-24 | — | — | WO | disclosed |