Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.41 |
| ▸ | ALOX5AP | P20292 | 6/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.39 |
| ▸ | SMO | Q99835 | 3/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2248075 | 0.89 | ALOX5AP (0.39) | ALDH1A1HPGDADAMTS4PARP10ALOX5AP | |
| SCHEMBL2244348 | 0.84 | SYK (0.41) | ALDH1A1ADAMTS4ALOX5APMAPK14SMO | |
| SCHEMBL13902762 | 0.84 | SYK (0.40) | ALDH1A1HPGDADAMTS4PARP10ALOX5AP | |
| SCHEMBL13248365 | 0.83 | MEN1 (0.56) | ADAMTS4MAOBPARP10 | |
| SCHEMBL2996834 | 0.78 | ADAMTS4 (0.46) | ALDH1A1HPGDADAMTS4MAOBDHODH | |
| SCHEMBL2251349 | 0.78 | PARP10 (0.57) | ALDH1A1HPGDADAMTS4MAOBDHODH | |
| SCHEMBL13248366 | 0.76 | NPSR1 (0.45) | PARP10ALOX5APCYP2C9 | |
| SCHEMBL2992851 | 0.76 | PARP10 (0.57) | ALDH1A1ADAMTS4MAOBPARP10 | |
| SCHEMBL2253252 | 0.75 | PARP10 (0.74) | ALDH1A1HPGDADAMTS4MAOBPARP10 | |
| SCHEMBL2246846 | 0.75 | NPC1 (0.53) | ALDH1A1ADAMTS4MAOBPARP10ALOX5AP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2546232-A1 | Diphenyl Substituted Alkanes | Merck Sharp & Dohme Corp. (US) | 2013-01-16 | — | — | EP | disclosed |
| US-20100190761-A1 | DIPHENYL SUBSTITUTED ALKANES | MERCK SHARP & DOHME CORP. | 2010-07-29 | — | — | US | disclosed |
| WO-2008156721-A1 | DIPHENYL SUBSTITUTED ALKANES | MERCK & CO., INC. (US) | 2008-12-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100190761-A1 | DIPHENYL SUBSTITUTED ALKANES | ALOX5, ALOX15, ALOX15B | KDM4C 3676/4885ALDH1A1 159/4885HPGD 223/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.