Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.38 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 4/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13248369 | 0.89 | KDM4C (0.47) | ALOX5APADAMTS4ALDH1A1CYP2C9HPGD | |
| SCHEMBL2244348 | 0.88 | SYK (0.41) | ALOX5APCYP19A1ADAMTS4ALDH1A1SMN1; SMN2 | |
| SCHEMBL13902762 | 0.87 | SYK (0.40) | ALOX5APCYP19A1ADAMTS4ALDH1A1SMN1; SMN2 | |
| SCHEMBL2250272 | 0.85 | ALOX5AP (0.52) | ALOX5APADAMTS4ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL2245019 | 0.81 | NPC1 (0.47) | SMN1; SMN2CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL2995823 | 0.78 | MAOB (0.45) | ADAMTS4ALDH1A1SMN1; SMN2KDM4ECYP1A2 | |
| SCHEMBL2246846 | 0.78 | NPC1 (0.53) | ALOX5APCYP19A1ADAMTS4ALDH1A1SMN1; SMN2 | |
| SCHEMBL2994531 | 0.77 | ALOX5AP (0.49) | ALOX5APADAMTS4ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL2242925 | 0.76 | ADAMTS4 (0.42) | CYP19A1ADAMTS4ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL2246698 | 0.76 | DHODH (0.41) | ALOX5APADAMTS4ALDH1A1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110190346-A1 | Diphenyl Substituted Alkanes as Flap Inhibitors | MERCK SHARP & DOHME CORP. (US) | 2011-08-04 | — | — | US | claimed |
| EP-1814877-B1 | DIPHENYL SUBSTITUTED ALKANES AS FLAP INHIBITORS | MERCK & CO INC (US) | 2009-03-11 | — | — | EP | claimed |
| US-20070287736-A1 | Diphenyl Substituted Alkanes as Flap Inhibitors | MERCK SHARP & DOHME CORP. | 2007-12-13 | — | — | US | claimed |
| EP-1814877-A2 | DIPHENYL SUBSTITUTED ALKANES AS FLAP INHIBITORS | Merck & Co., Inc. (US) | 2007-08-08 | — | — | EP | claimed |
| WO-2006044602-A9 | DIPHENYL SUBSTITUTED ALKANES AS FLAP INHIIBITORS | MERCK & CO INC (US) | 2006-06-08 | — | — | WO | claimed |
| WO-2006044602-A2 | DIPHENYL SUBSTITUTED ALKANES AS FLAP INHIIBITORS | MERCK & CO., INC. (US) | 2006-04-27 | — | — | WO | claimed |
| US-8729104-B2 | Diphenyl substituted alkanes as flap inhibitors | MERCK SHARP & DOHME CORP. (US) | 2014-05-20 | — | — | US | disclosed |
| US-20110190346-A1 | Diphenyl Substituted Alkanes as Flap Inhibitors | MERCK SHARP & DOHME CORP. (US) | 2011-08-04 | — | — | US | disclosed |
| EP-1814877-B1 | DIPHENYL SUBSTITUTED ALKANES AS FLAP INHIBITORS | MERCK & CO INC (US) | 2009-03-11 | — | — | EP | disclosed |
| US-20070287736-A1 | Diphenyl Substituted Alkanes as Flap Inhibitors | MERCK SHARP & DOHME CORP. | 2007-12-13 | — | — | US | disclosed |
| EP-1814877-A2 | DIPHENYL SUBSTITUTED ALKANES AS FLAP INHIBITORS | Merck & Co., Inc. (US) | 2007-08-08 | — | — | EP | disclosed |
| WO-2006044602-A9 | DIPHENYL SUBSTITUTED ALKANES AS FLAP INHIIBITORS | MERCK & CO INC (US) | 2006-06-08 | — | — | WO | disclosed |
| WO-2006044602-A2 | DIPHENYL SUBSTITUTED ALKANES AS FLAP INHIIBITORS | MERCK & CO., INC. (US) | 2006-04-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110190346-A1 | Diphenyl Substituted Alkanes as Flap Inhibitors | ALOX5, ALOX15, ALOX15B | ALOX5AP 10/4885CYP19A1 503/4885ADAMTS4 576/4885 |
| US-20070287736-A1 | Diphenyl Substituted Alkanes as Flap Inhibitors | ALOX5, ALOX15, ALOX15B | ALOX5AP 10/4885CYP19A1 503/4885ADAMTS4 576/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.