Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 6/20 | 0.48 |
| ▸ | BRD4 | O60885 | 7/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.34 |
| ▸ | USP1 | O94782 | 2/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1390239 | 1.00 | GPBAR1 (0.48) | GPBAR1BRD4PIK3CAPIK3CBUSP1 | |
| SCHEMBL1389894 | 0.90 | GPBAR1 (0.49) | GPBAR1BRD4 | |
| SCHEMBL1389891 | 0.90 | GPBAR1 (0.49) | GPBAR1BRD4 | |
| SCHEMBL1390307 | 0.89 | BRD4 (0.39) | GPBAR1BRD4PIK3CAPIK3CBUSP1 | |
| SCHEMBL1390241 | 0.88 | BRD4 (0.36) | GPBAR1BRD4HDAC6L3MBTL1 | |
| SCHEMBL1389600 | 0.86 | GPBAR1 (0.59) | GPBAR1BRD4L3MBTL1 | |
| SCHEMBL1389603 | 0.86 | GPBAR1 (0.59) | GPBAR1BRD4L3MBTL1 | |
| SCHEMBL1389601 | 0.86 | GPBAR1 (0.59) | GPBAR1BRD4L3MBTL1 | |
| SCHEMBL1389808 | 0.83 | GPBAR1 (0.64) | GPBAR1BRD4 | |
| SCHEMBL371106 | 0.83 | GPBAR1 (0.64) | GPBAR1BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593426-B1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | HOFFMANN LA ROCHE (CH) | 2014-08-20 | — | — | EP | claimed |
| EP-2593426-B1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | HOFFMANN LA ROCHE (CH) | 2014-08-20 | — | — | EP | disclosed |
| US-8765730-B2 | 1-hydroxyimino-3-phenyl-propanes | Hoffmann-La Roche Inc (US) | 2014-07-01 | — | — | US | disclosed |
| US-20120010190-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120010190-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | GPBAR1, GPR119, ADRB1 | GPBAR1 1/4885BRD4 3540/4885PIK3CA 3822/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.