Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | P2RY12 | Q9H244 | 10/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.36 |
| ▸ | PLAU | P00749 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.34 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.34 |
| ▸ | CCR9 | P51686 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13908072 | 0.84 | PLAU (0.36) | MAPTRAB9ANPC1GAAEGLN1 | |
| SCHEMBL2971896 | 0.84 | CCR9 (0.48) | LMNAP2RY12CCR9 | |
| SCHEMBL24510170 | 0.74 | CYP2C9 (0.45) | LMNAMAPTRAB9AMEN1NPC1 | |
| SCHEMBL13908050 | 0.73 | — | — | |
| SCHEMBL12955953 | 0.71 | ALDH1A1 (0.39) | LMNAMAPTRAB9ANPC1GAA | |
| SCHEMBL2969168 | 0.71 | CCR9 (0.49) | LMNACCR9 | |
| SCHEMBL2972076 | 0.70 | HSD17B2 (0.49) | EGLN1CCR9 | |
| SCHEMBL15578611 | 0.69 | ALKBH1 (0.48) | LMNARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL23609426 | 0.69 | P2RY12 (0.48) | P2RY12 | |
| SCHEMBL2969998 | 0.69 | HSD17B2 (0.47) | CCR9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009038847-A1 | N-(2-(HETARYL)ARYL)ARYLSULFONAMIDES AND N-(2-(HETARYL)HETARYL)ARYLSULFONAMIDES | CHEMOCENTRYX, INC. (US) | 2009-03-26 | — | — | WO | disclosed |