Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | CCR9 | P51686 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | IKBKB | O14920 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.35 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | PLAU | P00749 | 1/20 | 0.34 |
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | DHPS | P49366 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14303218 | 0.82 | CCR9 (0.33) | ALDH1A1CCR9POLBGAAHSD17B2 | |
| SCHEMBL14303215 | 0.81 | BACE1 (0.34) | CCR9SMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL14303638 | 0.77 | CCR9 (0.35) | CCR9HSD17B2 | |
| SCHEMBL13908072 | 0.73 | PLAU (0.36) | CCR9SMN1; SMN2POLBGAASERPINE1 | |
| SCHEMBL13908074 | 0.71 | LMNA (0.40) | CCR9SMN1; SMN2GAANPC1RAB9A | |
| SCHEMBL11938270 | 0.69 | CCR9 (0.68) | CCR9SMN1; SMN2POLBGAASERPINE1 | |
| SCHEMBL12703497 | 0.69 | BRAF (0.59) | — | |
| SCHEMBL12161641 | 0.68 | RAB9A (0.56) | ALDH1A1SMN1; SMN2POLBGAASERPINE1 | |
| SCHEMBL11936681 | 0.68 | CCR9 (0.53) | CCR9SMN1; SMN2POLBSERPINE1LMNA | |
| SCHEMBL11937065 | 0.68 | CCR9 (0.52) | CCR9GAASERPINE1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049515-B1 | TRIAZOLYL PYRIDYL BENZENESULFONAMIDES AS CCR2 OR CCR9 MODULATORS FOR THE TREATMENT OF ATHEROSCLEROSIS | CHEMOCENTRYX INC (US) | 2011-01-26 | — | — | EP | disclosed |