Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 7/20 | 1.00 |
| ▸ | HPGD | P15428 | 6/20 | 1.00 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 1.00 |
| ▸ | LMNA | P02545 | 5/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 4/20 | 1.00 |
| ▸ | HTT | P42858 | 3/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.73 |
| ▸ | USP2 | O75604 | 2/20 | 0.73 |
| ▸ | SDHB | P21912 | 7/20 | 0.66 |
| ▸ | STAT3 | P40763 | 3/20 | 0.66 |
| ▸ | MITF | O75030 | 2/20 | 0.66 |
| ▸ | STAT1 | P42224 | 2/20 | 0.66 |
| ▸ | RAB9A | P51151 | 2/20 | 0.66 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.66 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | POLB | P06746 | 2/20 | 0.64 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19805682 | 0.84 | NPSR1 (1.00) | TP53HPGDNPSR1SMN1; SMN2LMNA | |
| SCHEMBL29976593 | 0.83 | NPSR1 (0.70) | TP53HPGDNPSR1SMN1; SMN2LMNA | |
| SCHEMBL19805681 | 0.81 | SDHB (0.78) | TP53HPGDNPSR1SMN1; SMN2LMNA | |
| SCHEMBL4721292 | 0.81 | SDHB (0.81) | TP53HPGDNPSR1SMN1; SMN2LMNA | |
| SCHEMBL29976202 | 0.81 | SDHB (1.00) | SDHB | |
| SCHEMBL19805692 | 0.81 | SDHB (1.00) | SDHB | |
| SCHEMBL4504428 | 0.80 | KMT2A (0.67) | TP53HPGDNPSR1SMN1; SMN2LMNA | |
| SCHEMBL19805665 | 0.80 | NPSR1 (1.00) | TP53HPGDNPSR1SMN1; SMN2LMNA | |
| SCHEMBL19805673 | 0.80 | SDHB (1.00) | TP53HPGDNPSR1SMN1; SMN2LMNA | |
| SCHEMBL19805677 | 0.80 | NPSR1 (1.00) | TP53HPGDNPSR1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090069324-A1 | CHEMICAL INHIBITORS OF BFL-1 AND RELATED METHODS | THE BURNHAM INSTITUTE (US) | 2009-03-12 | — | — | US | disclosed |
| US-20090069324-A1 | CHEMICAL INHIBITORS OF BFL-1 AND RELATED METHODS | THE BURNHAM INSTITUTE (US) | 2009-03-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090069324-A1 | CHEMICAL INHIBITORS OF BFL-1 AND RELATED METHODS | TMBIM6, BCL2L1, BCL2L11 | TP53 204/4885HPGD 3488/4885NPSR1 4806/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.