Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SDHB | P21912 | 5/20 | 0.81 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.81 |
| ▸ | LMNA | P02545 | 3/20 | 0.81 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.81 |
| ▸ | STAT3 | P40763 | 2/20 | 0.81 |
| ▸ | STAT1 | P42224 | 2/20 | 0.81 |
| ▸ | RAB9A | P51151 | 2/20 | 0.81 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.81 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.81 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.81 |
| ▸ | MITF | O75030 | 1/20 | 0.81 |
| ▸ | TP53 | P04637 | 3/20 | 0.78 |
| ▸ | HPGD | P15428 | 3/20 | 0.78 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.78 |
| ▸ | HTT | P42858 | 2/20 | 0.78 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.78 |
| ▸ | MEN1 | O00255 | 1/20 | 0.78 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.78 |
| ▸ | POLB | P06746 | 1/20 | 0.78 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.78 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19805665 | 0.90 | NPSR1 (1.00) | SDHBNPSR1LMNASMN1; SMN2STAT3 | |
| SCHEMBL19805673 | 0.90 | SDHB (1.00) | SDHBNPSR1LMNASMN1; SMN2STAT3 | |
| SCHEMBL29975914 | 0.88 | NPSR1 (1.00) | SDHBNPSR1LMNASMN1; SMN2STAT3 | |
| SCHEMBL28307436 | 0.88 | NPSR1 (1.00) | SDHBNPSR1LMNASMN1; SMN2STAT3 | |
| SCHEMBL19805682 | 0.86 | NPSR1 (1.00) | SDHBNPSR1LMNASMN1; SMN2STAT3 | |
| SCHEMBL19805683 | 0.85 | SDHB (0.71) | SDHBNPSR1LMNASMN1; SMN2STAT3 | |
| SCHEMBL29977030 | 0.85 | SDHB (0.71) | SDHBNPSR1LMNASMN1; SMN2STAT3 | |
| SCHEMBL19805679 | 0.85 | SDHB (0.71) | SDHBNPSR1LMNASMN1; SMN2STAT3 | |
| SCHEMBL19805686 | 0.85 | SDHB (0.73) | SDHBNPSR1LMNASMN1; SMN2STAT3 | |
| SCHEMBL5785867 | 0.84 | PTGS2 (1.00) | SDHBNPSR1LMNASMN1; SMN2STAT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1493735-B1 | PYRIMIDINE DERIVATIVES USEFUL AS SELECTIVE COX-2 INHIBITORS | GLAXO GROUP LTD (GB) | 2008-10-29 | — | — | EP | disclosed |
| US-20070270428-A1 | Use of Cyclooxygenase-2 Inhibitors for the Treatment of Depressive Disorders | GLAXO GROUP LIMITED (GB) | 2007-11-22 | — | — | US | disclosed |
| US-20060194824-A1 | Compositions containing pyrimidine derivatives as inhibitors of cox-2 | GLAXO GROUP LIMITED (GB) | 2006-08-31 | — | — | US | disclosed |
| EP-1687001-A2 | USE OF CYCLOOXYGENASE-2 SELECTIVE INHIBITORS FOR THE TREATMENT OF SCHIZOPHRENIC DISORDERS | GLAXO GROUP LIMITED (GB) | 2006-08-09 | — | — | EP | disclosed |
| EP-1687000-A2 | USE OF CYCLOOXYGENASE-2 INHIBITORS FOR THE TREATMENT OF DEPRESSIVE DISORDERS | GLAXO GROUP LIMITED (GB) | 2006-08-09 | — | — | EP | disclosed |
| US-7084148-B2 | Substituted pyrimidines as selective cyclooxygenase-2 inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 2006-08-01 | — | — | US | disclosed |
| CN-1255387-C | Pyrimidine derivatives useful as selective COX-2 inhibitors | GLAXO GROUP LTD (GB) | 2006-05-10 | — | — | CN | disclosed |
| EP-1390351-B1 | PYRIMIDINE DERIVATIVES USEFUL AS SELECTIVE COX-2 INHIBITORS | GLAXO GROUP LTD (GB) | 2006-05-03 | — | — | EP | disclosed |
| EP-1254119-B1 | PYRIMIDINE DERIVATIVES AS SELECTIVE INHIBITORS OF COX-2 | GLAXO GROUP LTD (GB) | 2006-04-12 | — | — | EP | disclosed |
| US-7026327-B2 | Pyrimidine derivatives useful as selective COX-2 inhibitors | GLAXO GROUP LIMITED (GB) | 2006-04-11 | — | — | US | disclosed |
| EP-1390351-A1 | PYRIMIDINE DERIVATIVES USEFUL AS SELECTIVE COX-2 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2004-02-25 | — | — | EP | disclosed |
| US-20030109538-A1 | Pyrmidine derivatives as selective inhibitors of cox-2 | SMITHKLINE BEECHAM CORPORATION | 2003-06-12 | — | — | US | disclosed |
| EP-1313728-A1 | SUBSTITUTED PYRIMIDINES AS SELECTIVE CYCLOOXYGENASE-2 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2003-05-28 | — | — | EP | disclosed |
| CN-1399633-A | Pyrimidine derivatives | GLAXO GROUP LTD (GB) | 2003-02-26 | — | — | CN | disclosed |
| WO-2002096885-A1 | PYRIMIDINE DERIVATIVES USEFUL AS SELECTIVE COX-2 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2002-12-05 | — | — | WO | disclosed |
| EP-1254119-A1 | PYRIMIDINE DERIVATIVES AS SELECTIVE INHIBITORS OF COX-2 | GLAXO GROUP LIMITED (GB) | 2002-11-06 | — | — | EP | disclosed |
| EP-1235812-A2 | PYRIMIDINE DERIVATIVES AS SELECTIVE INHIBITORS OF COX-2 | GLAXO GROUP LIMITED (GB) | 2002-09-04 | — | — | EP | disclosed |
| WO-2002018374-A1 | SUBSTITUTED PYRIMIDINES AS SELECTIVE CYCLOOXYGENASE-2 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2002-03-07 | — | — | WO | disclosed |
| WO-2001058881-A1 | PYRIMIDINE DERIVATIVES AS SELECTIVE INHIBITORS OF COX-2 | GLAXO GROUP LIMITED (GB) | 2001-08-16 | — | — | WO | disclosed |
| WO-2001038311-A2 | PYRIMIDINE DERIVATIVES AS SELECTIVE INHIBITORS OF COX-2 | GLAXO GROUP LIMITED (GB) | 2001-05-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070270428-A1 | Use of Cyclooxygenase-2 Inhibitors for the Treatment of Depressive Disorders | TPH2, PTGS2, PTGES2 | SDHB 55/4885NPSR1 142/4885LMNA 4000/4885 |
| US-20060194824-A1 | Compositions containing pyrimidine derivatives as inhibitors of cox-2 | DPYD, PTGS2, TYMP | SDHB 187/4885NPSR1 2616/4885LMNA 4481/4885 |
| US-20030109538-A1 | Pyrmidine derivatives as selective inhibitors of cox-2 | PTGS1, PTGS2, PTGES2 | SDHB 203/4885NPSR1 552/4885LMNA 4389/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.