Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 4/20 | 0.59 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.59 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.59 |
| ▸ | ADORA1 | P30542 | 8/20 | 0.49 |
| ▸ | ELAVL1 | Q15717 | 1/20 | 0.46 |
| ▸ | PDE5A | O76074 | 1/20 | 0.45 |
| ▸ | PDE1A | P54750 | 1/20 | 0.45 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.45 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | GHSR | Q92847 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7013023 | 0.79 | ADORA3 (0.65) | ADORA2BADORA3ADORA2AADORA1ELAVL1 | |
| SCHEMBL4306407 | 0.78 | ADORA3 (0.64) | ADORA2BADORA3ADORA2AADORA1ELAVL1 | |
| SCHEMBL13914390 | 0.74 | ADORA2B (0.77) | ADORA2BADORA3ADORA2AADORA1ELAVL1 | |
| SCHEMBL4321220 | 0.74 | ADORA2B (1.00) | ADORA2BADORA3ADORA2AADORA1ELAVL1 | |
| SCHEMBL27569167 | 0.74 | ADORA3 (0.59) | ADORA2BADORA3ADORA2AADORA1ELAVL1 | |
| SCHEMBL13914393 | 0.73 | ADORA2B (0.74) | ADORA2BADORA3ADORA2AADORA1ELAVL1 | |
| SCHEMBL3556602 | 0.72 | ADORA2B (0.68) | ADORA2BADORA3ADORA2AADORA1ELAVL1 | |
| SCHEMBL27569170 | 0.72 | ADORA2A (0.57) | ADORA2BADORA3ADORA2AADORA1ALDH1A1 | |
| SCHEMBL13914391 | 0.72 | ADORA2B (0.73) | ADORA2BADORA3ADORA2AADORA1ELAVL1 | |
| SCHEMBL3548045 | 0.72 | ADORA3 (0.56) | ADORA2BADORA3ADORA2AADORA1ELAVL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7504421-B2 | Substituted 2-thio-3,5-dicyano-4-aryl-6-aminopyridines and their use | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2009-03-17 | — | — | US | disclosed |
| US-7504421-B2 | Substituted 2-thio-3,5-dicyano-4-aryl-6-aminopyridines and their use | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2009-03-17 | — | — | US | disclosed |