Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | PKM | P14618 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.51 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.51 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.51 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.51 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3880694 | 0.85 | HTR2A (0.55) | ALDH1A1PKMGAAKDM4EMEN1 | |
| SCHEMBL3868079 | 0.85 | ALDH1A1 (0.58) | ALDH1A1PKMGAAKDM4EMEN1 | |
| SCHEMBL6556991 | 0.82 | GBA1 (0.43) | ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL8885165 | 0.79 | ALDH1A1 (0.63) | ALDH1A1PKMGAAKDM4EMEN1 | |
| SCHEMBL13888771 | 0.79 | ALDH1A1 (0.63) | ALDH1A1PKMGAAKDM4EMEN1 | |
| SCHEMBL8223285 | 0.79 | ALDH1A1 (0.63) | ALDH1A1PKMGAAKDM4EMEN1 | |
| SCHEMBL14470092 | 0.78 | MEN1 (0.81) | ALDH1A1PKMGAAMEN1KMT2A | |
| SCHEMBL21541890 | 0.77 | SLC6A2 (0.47) | ALDH1A1PKMGAAPOLBNPC1 | |
| SCHEMBL13152700 | 0.76 | ALDH1A1 (0.60) | ALDH1A1PKMGAAKDM4EMEN1 | |
| SCHEMBL9217317 | 0.76 | HTR2A (0.55) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7491727-B2 | Good selectivity, high affinity, metabolically stable 5-HT receptor modulators with good bioavailability, CNS penetration, and good pharmacokinetic; antiserotonine agents; central nervous system disorders; anxiolytic agents; attention deficit disorders; strokes; headaches | EPIX DELAWARE, INC. (US) | 2009-02-17 | — | — | US | disclosed |
| US-7488731-B2 | Arylpiperazinyl compounds | EPIX DELAWARE, INC. (US) | 2009-02-10 | — | — | US | disclosed |
| US-20080027066-A1 | Arylpiperazinyl Compounds | EPIX DELAWARE, INC. | 2008-01-31 | — | — | US | disclosed |
| US-20070004742-A1 | Arylpiperazinyl compounds | EPIX DELAWARE, INC. | 2007-01-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080027066-A1 | Arylpiperazinyl Compounds | HTR5A, HTR1A, HTR2A | ALDH1A1 346/4885PKM 2188/4885GAA 1163/4885 |
| US-20070004742-A1 | Arylpiperazinyl compounds | HTR5A, HTR1A, HTR2A | ALDH1A1 346/4885PKM 2188/4885GAA 1163/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.