Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK5 | Q8IW41 | 4/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.31 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.31 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.31 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 5/20 | 0.31 |
| ▸ | BRD4 | O60885 | 2/20 | 0.31 |
| ▸ | JAK3 | P52333 | 4/20 | 0.31 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.31 |
| ▸ | WEE1 | P30291 | 2/20 | 0.30 |
| ▸ | JAK1 | P23458 | 1/20 | 0.30 |
| ▸ | BRD2 | P25440 | 1/20 | 0.30 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.30 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.30 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.30 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10134512 | 0.89 | MAPKAPK5 (0.48) | MAPKAPK5ROCK2SYKZAP70TLR9 | |
| SCHEMBL10133578 | 0.88 | MAPKAPK5 (0.49) | MAPKAPK5ROCK2SYKZAP70JAK2 | |
| SCHEMBL10134523 | 0.88 | MAPKAPK5 (0.49) | MAPKAPK5ROCK2JAK2BRD4JAK3 | |
| SCHEMBL13922281 | 0.86 | MAPKAPK5 (0.45) | MAPKAPK5ROCK2SYKZAP70JAK2 | |
| SCHEMBL13922280 | 0.85 | MAPKAPK5 (0.48) | MAPKAPK5SYK | |
| SCHEMBL12618871 | 0.84 | MAPKAPK5 (0.49) | MAPKAPK5ROCK2ZAP70TLR9TLR8 | |
| SCHEMBL13922211 | 0.84 | MAPKAPK5 (0.36) | MAPKAPK5ROCK2ZAP70TLR9TLR8 | |
| SCHEMBL1685281 | 0.83 | MAPKAPK5 (0.45) | MAPKAPK5ROCK2ZAP70TLR9TLR8 | |
| SCHEMBL13922272 | 0.83 | MAPKAPK5 (0.43) | MAPKAPK5ROCK2ZAP70JAK1SCN8A | |
| SCHEMBL12619378 | 0.83 | MAPKAPK5 (0.46) | MAPKAPK5ROCK2ZAP70TLR9TLR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090048245-A1 | Imidazolopyridine compounds useful for the treatment of degenerative and inflammatory diseases | GALAPAGOS NV (BE) | 2009-02-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090048245-A1 | Imidazolopyridine compounds useful for the treatment of degenerative and inflammatory diseases | COL2A1, MMP1, COL1A1 | MAPKAPK5 19/4885ROCK2 1106/4885SYK 1605/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.