Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | CDK4 | P11802 | 1/20 | 0.35 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.35 |
| ▸ | NPY2R | P49146 | 4/20 | 0.35 |
| ▸ | JAK2 | O60674 | 2/20 | 0.34 |
| ▸ | EGFR | P00533 | 2/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.32 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.32 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.32 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13922284 | 0.87 | MAPKAPK5 (0.39) | SYKMAPKAPK5 | |
| SCHEMBL1685218 | 0.80 | MAPKAPK5 (0.44) | KDM4ECSF1RCDK4CDK6NPY2R | |
| SCHEMBL1685198 | 0.78 | MAPKAPK5 (0.48) | KDM4ECSF1RCDK4CDK6NPY2R | |
| SCHEMBL10134531 | 0.77 | MAPKAPK5 (0.48) | KDM4ECSF1RCDK4CDK6JAK2 | |
| SCHEMBL1685128 | 0.77 | MAPKAPK5 (0.43) | CSF1RCDK4CDK6JAK2SYK | |
| SCHEMBL1685139 | 0.76 | MAPKAPK5 (0.48) | CSF1RCDK4CDK6JAK2FLT3 | |
| SCHEMBL13922414 | 0.75 | F12 (0.39) | FLT3SYKMAPKAPK5 | |
| SCHEMBL3879195 | 0.75 | SYK (0.38) | CSF1RCDK4CDK6NPY2RJAK2 | |
| SCHEMBL10134591 | 0.71 | MAPKAPK5 (0.46) | KDM4ECSF1RJAK2FLT3BTK | |
| SCHEMBL12618516 | 0.71 | HTT (0.46) | JAK2MAPKAPK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090048245-A1 | Imidazolopyridine compounds useful for the treatment of degenerative and inflammatory diseases | GALAPAGOS NV (BE) | 2009-02-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090048245-A1 | Imidazolopyridine compounds useful for the treatment of degenerative and inflammatory diseases | COL2A1, MMP1, COL1A1 | KDM4E 3092/4885CSF1R 942/4885CDK4 167/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.