Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 3/20 | 0.46 |
| ▸ | SMYD3 | Q9H7B4 | 8/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | CCND1 | P24385 | 2/20 | 0.32 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.32 |
| ▸ | CDK2 | P24941 | 2/20 | 0.32 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8342421 | 0.92 | EPHX2 (0.51) | EPHX2SMYD3TSHRL3MBTL1 | |
| SCHEMBL23564023 | 0.88 | EPHX2 (0.40) | EPHX2SMYD3TSHRL3MBTL1TP53 | |
| SCHEMBL6118668 | 0.80 | EPHX2 (0.47) | EPHX2SMYD3TSHRL3MBTL1JAK1 | |
| SCHEMBL5344959 | 0.80 | TP53 (0.50) | EPHX2SMYD3TSHRL3MBTL1TP53 | |
| SCHEMBL9034989 | 0.80 | CA1 (0.42) | EPHX2SMYD3TSHRL3MBTL1TP53 | |
| SCHEMBL8978497 | 0.78 | L3MBTL1 (0.53) | EPHX2SMYD3TSHRL3MBTL1TP53 | |
| SCHEMBL14037777 | 0.76 | EPHX2 (0.41) | EPHX2SMYD3TSHRL3MBTL1 | |
| SCHEMBL8978496 | 0.75 | ALDH1A1 (0.55) | CCNE1CDK2 | |
| SCHEMBL14618813 | 0.75 | EPHX2 (0.51) | EPHX2TSHRL3MBTL1JAK1CCND1 | |
| SCHEMBL23973911 | 0.75 | ADH1B (0.50) | EPHX2SMYD3JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009016460-A2 | PYRAZOLE COMPOUNDS AND THEIR USE AS RAF INHIBITORS | PFIZER INC. (US) | 2009-02-05 | — | — | WO | disclosed |