Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.41 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.41 |
| ▸ | NOS1 | P29475 | 6/20 | 0.40 |
| ▸ | METAP2 | P50579 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7221088 | 0.98 | CHEK1 (0.46) | CHEK1MAPTKDM4EMEN1KMT2A | |
| SCHEMBL10235446 | 0.81 | TRPA1 (0.43) | CHEK1MAPTKDM4EMEN1KMT2A | |
| SCHEMBL4996798 | 0.81 | DYRK1A (0.48) | CHEK1MAPTKDM4EMEN1KMT2A | |
| SCHEMBL15541878 | 0.81 | CHEK1 (0.42) | CHEK1MAPTKDM4EMEN1KMT2A | |
| SCHEMBL21938565 | 0.78 | PIM1 (0.50) | CHEK1MAPTKDM4EMEN1KMT2A | |
| SCHEMBL23119370 | 0.77 | NOS1 (0.41) | CHEK1MAPTKDM4EMEN1KMT2A | |
| SCHEMBL20627222 | 0.77 | CHEK1 (0.39) | CHEK1MAPTKDM4EMEN1KMT2A | |
| SCHEMBL16371204 | 0.74 | CHEK1 (0.57) | CHEK1MAPTKDM4EMEN1KMT2A | |
| SCHEMBL31391737 | 0.73 | FGFR1 (0.40) | CHEK1MAPTKDM4EMEN1KMT2A | |
| SCHEMBL23901315 | 0.73 | FGFR1 (0.40) | CHEK1MAPTKDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7482357-B2 | 17-acetamido-4-azasteroid derivatives as androgen receptor modulators | MERCK & CO., INC. (US) | 2009-01-27 | — | — | US | disclosed |
| US-7482357-B2 | 17-acetamido-4-azasteroid derivatives as androgen receptor modulators | MERCK & CO., INC. (US) | 2009-01-27 | — | — | US | disclosed |