Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 4/20 | 0.50 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.50 |
| ▸ | GSK3B | P49841 | 3/20 | 0.50 |
| ▸ | JAK2 | O60674 | 2/20 | 0.50 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.50 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.50 |
| ▸ | AURKA | O14965 | 1/20 | 0.50 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.50 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.50 |
| ▸ | CDK2 | P24941 | 1/20 | 0.50 |
| ▸ | MARK3 | P27448 | 1/20 | 0.50 |
| ▸ | GSK3A | P49840 | 1/20 | 0.50 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.50 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.50 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.50 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.50 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | AXL | P30530 | 1/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 4/20 | 0.40 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10235446 | 0.85 | TRPA1 (0.43) | PIM1ROCK2GSK3BJAK2ROCK1 | |
| SCHEMBL13940969 | 0.78 | CHEK1 (0.47) | PIM1ROCK2GSK3BROCK1CDK2 | |
| SCHEMBL15541878 | 0.78 | CHEK1 (0.42) | PIM1ROCK2GSK3BROCK1CDK2 | |
| SCHEMBL4996798 | 0.78 | DYRK1A (0.48) | PIM1ROCK2GSK3BJAK2ROCK1 | |
| SCHEMBL25107119 | 0.78 | PIM1 (0.39) | PIM1ROCK2GSK3BJAK2ROCK1 | |
| SCHEMBL20627222 | 0.77 | CHEK1 (0.39) | PIM1ROCK2GSK3BJAK2ROCK1 | |
| SCHEMBL23119370 | 0.77 | NOS1 (0.41) | PIM1ROCK2GSK3BJAK2ROCK1 | |
| Hydrochloric Acid SCHEMBL7221088 | 0.76 | CHEK1 (0.46) | PIM1ROCK2GSK3BROCK1CDK2 | |
| SCHEMBL24493489 | 0.74 | GABRP (0.41) | GABRPGABRDGABRA1IDO1GABRB1 | |
| SCHEMBL8220180 | 0.71 | ROCK2 (0.54) | PIM1ROCK2GSK3BJAK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2986624-B1 | 19-NOR NEUROACTIVE STEROIDS FOR METHODS OF TREATMENT | SAGE THERAPEUTICS INC (US) | 2020-03-25 | — | — | EP | disclosed |